发明授权
- 专利标题: Aminoindan derivatives
- 专利标题(中): 氨基茚衍生物
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申请号: US09336493申请日: 1999-06-18
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公开(公告)号: US06303650B1公开(公告)日: 2001-10-16
- 发明人: Michael Chorev , Tamar Goren , Yacov Herzig , Jeffrey Sterling , Marta Weinstock-Rosin , Moussa B. H. Youdim
- 申请人: Michael Chorev , Tamar Goren , Yacov Herzig , Jeffrey Sterling , Marta Weinstock-Rosin , Moussa B. H. Youdim
- 主分类号: A61K3127
- IPC分类号: A61K3127
摘要:
This invention is directed to compounds of the following formula wherein when a is O, b is 1 or 2; when a is 1, b is 1, m is from 0-3 X is O or S, Y is halogeno, R1 is hydrogen C1-4 alkyl, R2 is hydrogen, C1-4 alkyl, or optionally substituted propargyl and R3 and R4 are each independently hydrogen, C1-8 alkyl, C6-12 aryl, C6-12 aralkyl each optionally substituted. This invention is also directed to the use of these compounds for treating depression, Attention Deficit Disorder (ADC), Attention Deficit and Hyperactivity Disorder (ADHD), Tourette's Syndrome, Alzheimer's Disease and other dementia's such as senile dementia, dementia of the Parkinson's type, vascular dementia and Lewy body dementia. This invention is further directed to a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.
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