发明授权
US06306306B1 Chromatographic process for obtaining highly purified cyclosporin A and related cyclosporins
失效
用于获得高度纯化的环孢菌素A和相关环孢菌素的色谱法
- 专利标题： Chromatographic process for obtaining highly purified cyclosporin A and related cyclosporins
- 专利标题（中）： 用于获得高度纯化的环孢菌素A和相关环孢菌素的色谱法
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申请号： US08821823申请日： 1997-03-21
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公开(公告)号： US06306306B1公开(公告)日： 2001-10-23
- 发明人: Ulrich Voigt , Joachim Kinkel , Roland Hempel , Roger-Marc Nicoud
- 申请人： Ulrich Voigt , Joachim Kinkel , Roland Hempel , Roger-Marc Nicoud
- 优先权： DE19611094 19960321
- 主分类号： B01D1508
- IPC分类号： B01D1508
摘要：
The present invention relates to a novel chromatographic process which is suitable for the purification of cyclosporin-containing crude extracts on industrial scale. In this process, the conventional preparative chromatographic separation methods are completely or at least partially replaced by the simulated moving bed method (SMB). The cyclosporin A obtained corresponds both to the quality requirements of USP XXIII and of EUROPEAN PHARMACOPOEIA, 2nd Edition 1995.
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