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    Chromatographic process for obtaining highly purified cyclosporin A and related cyclosporins
    4.
    发明授权
    Chromatographic process for obtaining highly purified cyclosporin A and related cyclosporins 失效
    用于获得高度纯化的环孢菌素A和相关环孢菌素的色谱法

    公开(公告)号：US06306306B1

    公开(公告)日：2001-10-23

    申请号：US08821823

    申请日：1997-03-21

    申请人： Ulrich Voigt ,  Joachim Kinkel ,  Roland Hempel ,  Roger-Marc Nicoud

    发明人： Ulrich Voigt ,  Joachim Kinkel ,  Roland Hempel ,  Roger-Marc Nicoud

    IPC分类号： B01D1508

    CPC分类号： C07K7/645 ,  A61K38/00

    摘要： The present invention relates to a novel chromatographic process which is suitable for the purification of cyclosporin-containing crude extracts on industrial scale. In this process, the conventional preparative chromatographic separation methods are completely or at least partially replaced by the simulated moving bed method (SMB). The cyclosporin A obtained corresponds both to the quality requirements of USP XXIII and of EUROPEAN PHARMACOPOEIA, 2nd Edition 1995.

    摘要翻译： 本发明涉及一种适用于工业规模纯化含环孢菌素的粗提物的新型色谱法。 在此过程中，传统的制备色谱分离方法完全或至少部分被模拟移动床法（SMB）所取代。 获得的环孢菌素A均符合USP XXIII和欧洲药典（USPOPEAN PHARMACOPOEIA）1995年第2版的质量要求。

    Separating materials
    9.
    发明授权
    Separating materials 失效
    分离材料

    公开(公告)号：US5453186A

    公开(公告)日：1995-09-26

    申请号：US376656

    申请日：1995-01-20

    申请人： Werner Muller ,  Joachim Kinkel

    发明人： Werner Muller ,  Joachim Kinkel

    IPC分类号： B01J20/285 ,  B01D15/08 ,  B01J20/32 ,  B01J39/16 ,  B01J39/20 ,  B01J39/26 ,  B01J41/08 ,  B01J41/14 ,  B01J41/20 ,  G01N30/88

    CPC分类号： B01J39/20 ,  B01D15/08 ,  B01J20/3278 ,  B01J41/14 ,  B01D15/361 ,  B01D15/3804

    摘要： The invention is directed to separating materials comprising a primary or secondary aliphatic hydroxyl group-containing support coated with at least one covalently bonded polymer, wherein(1) the covalently bonded polymers are bonded to the support by graft polymerization via the .alpha.-carbon atoms of the hydroxyl groups, and(2) the polymer contains identical or different recurring units of the formula I ##STR1## wherein R.sup.1 is H or CH.sub.3 ;Y is ##STR2## R' and R" are each independently H or CH.sub.3, R.sup.2 and R.sup.3 are each independently(a) C.sub.1-10 -alkyl, phenyl, phenyl-C.sub.1-10 -alkyl, cycloalkyl, C.sub.1-10 -alkyl-cycloalkyl or C.sub.1-10 -alkylphenyl,(b) one of the above groups in (a) monosubstituted or polysubstituted by each of amino, mono- or dialkylamino, trialkylammonium, carboxyl, or sulfonyl,(c) a cyclic or bicyclic radical having 5-10 C atoms, wherein one or more CH or CH.sub.2 groups is replaced by (i) N or NH, (ii) N or NH and S, or (iii) N or NH and O, or(d) one of R.sup.2 or R.sup.3 is H; and wherein R.sup.2 and R.sup.3 are coordinated with one another so that either both radicals are acidic or basic, or one of the radicals is neutral and one is acidic or basic,x is 2 to 100,and R.sup.4 is C.sub.1-10 -alkyl, phenyl, phenyl-C.sub.1-10 -alkyl, cycloalkyl or C.sub.1-10 -alkyl-cycloalkyl, or C.sub.1-10 -cyclophenyl, each monosubstituted or polysubstituted by carboxyl or sulfonyl.

    摘要翻译： 本发明涉及包含含有至少一种共价键合的聚合物的伯或仲脂族羟基的载体的分离材料，其中（1）通过接枝聚合将共价键合的聚合物经由α-碳原子 羟基，和（2）聚合物含有相同或不同的式I的重复单元，其中R 1是H或CH 3; Y是R'和R“各自独立地是H或CH 3，R 2和R 3各自独立地为（a）C 1-10烷基，苯基，苯基-C 1-10烷基，环烷基，C 1-10 - 烷基 （a）由氨基，单或二烷基氨基，三烷基铵，羧基或磺酰基中的每一个单取代或多取代的上述基团之一，（c）环或二环基团，其具有 5-10个C原子，其中一个或多个CH或CH 2基团被（i）N或NH，（ii）N或NH和S或（iii）N或NH和O，或（d）R2 或R 3为H; 并且其中R2和R3彼此配位，使得两个基团都是酸性或碱性的，或者一个基团是中性的，一个是酸性或碱性的，x是2至100，并且R 4是C 1-10 - 烷基，苯基 ，苯基-C 1-10烷基，环烷基或C 1-10 - 烷基 - 环烷基，或被羧基或磺酰基单取代或多取代的C 1-10 - 环苯基。