发明授权
- 专利标题： Sugar modified oligonucleotides that detect and modulate gene expression
- 专利标题（中）： 检测和调节基因表达的糖修饰寡核苷酸
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申请号： US08936166申请日： 1997-09-23
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公开(公告)号： US06307040B1公开(公告)日： 2001-10-23
- 发明人: Philip Dan Cook , Andrew M. Kawasaki
- 申请人： Philip Dan Cook , Andrew M. Kawasaki
- 主分类号： C07H2104
- IPC分类号： C07H2104
摘要：
Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2′-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of HIV, herpes virus, papillomavirus and other infections is provided.
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