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    Gene expression base sequences for therapeutic use and drugs for gene therapy
    6.
    发明授权
    Gene expression base sequences for therapeutic use and drugs for gene therapy 失效
    用于治疗用途的基因表达碱基序列和用于基因治疗的药物

    公开(公告)号：US06815430B1

    公开(公告)日：2004-11-09

    申请号：US09958021

    申请日：2002-01-07

    申请人： Kazuhiro Yuda ,  Katsuhiko Akiyama ,  Takeshi Goto ,  Katsuyuki Hamada

    发明人： Kazuhiro Yuda ,  Katsuhiko Akiyama ,  Takeshi Goto ,  Katsuyuki Hamada

    IPC分类号： C07H2104

    CPC分类号： C07K14/4731 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4748 ,  C12N15/63

    摘要： The base sequence for the expression of a therapeutic gene and the medicament for gene therapy are disclosed. There is also disclosed the base sequence for the expression of a therapeutic gene, said sequence being shown in any one of from (a) to (d) and capable of directing the expression of the therapeutic gene specifically to squamous epithelium: (a) the base sequence set forth in SEQ ID NO:1 in the Sequence Listing; (b) the base sequence set forth in SEQ ID NO:18 in the Sequence Listing; (c) the base sequence set forth in SEQ ID NO:17 in the Sequence Listing; and (d) the base sequence set forth in SEQ ID NO:16 in the Sequence Listing. Moreover, there is disclosed the medicament for gene therapy containing a therapeutic gene downstream any of the above-mentioned base sequences, capable of directing the expression of the therapeutic gene specifically to squamous epithelium.

    摘要翻译： 公开了用于表达治疗基因的碱基序列和用于基因治疗的药物。 还公开了用于表达治疗基因的碱基序列，所述序列显示为（a）至（d）中任一项，并且能够将治疗基因的表达特异性指导至鳞状上皮细胞：（a） 碱基序列;（b）序列表中SEQ ID NO：18所示的碱基序列;（c）SEQ ID NO：17所示的碱基序列， 序列表 和（d）序列表中SEQ ID NO：16所示的碱基序列。此外，公开了含有上述碱基序列下游的治疗基因的基因治疗药物，其能够指导 该治疗基因专门用于鳞状上皮细胞。

    Detection and diagnosis of smoking related cancers
    7.
    发明授权
    Detection and diagnosis of smoking related cancers 有权
    检测和诊断吸烟相关的癌症

    公开(公告)号：US06797471B2

    公开(公告)日：2004-09-28

    申请号：US09923304

    申请日：2001-08-06

    申请人： Ruth Katz ,  Feng Jiang

    发明人： Ruth Katz ,  Feng Jiang

    IPC分类号： C07H2104

    CPC分类号： C12Q1/6886 ,  C12Q2600/118

    摘要： Gene probes for specific regions of chromosome 3 (3p21.3) and chromosome 10 (10q22) have been found to be tools for the diagnosis and prognosis of smoking related cancers such as non-small cell lung cancer (NSCLC). For example, these probes can be used with fluorescence in situ hybridization (FISH), and used to stratify smokers into high and low risk groups, as well as determine a patients susceptibility to the development of smoking related cancers.

    摘要翻译： 已经发现染色体3（3p21.3）和染色体10（10q22）的特定区域的基因探针是用于诊断和预测与非小细胞肺癌（NSCLC）相关的吸烟相关癌症的工具。 例如，这些探针可以与荧光原位杂交（FISH）一起使用，并用于将吸烟者分为高危组和低危组，以及确定患者对吸烟相关癌症发展的易感性。

    Expression system in microorganism and its use for expressing heterologous and homologous proteins
    8.
    发明授权
    Expression system in microorganism and its use for expressing heterologous and homologous proteins 失效
    微生物中的表达系统及其用于表达异源和同源蛋白质的用途

    公开(公告)号：US06790951B1

    公开(公告)日：2004-09-14

    申请号：US09068507

    申请日：1998-07-15

    申请人： Vincent G. H. Eijsink ,  Ingolf F. Nes ,  May B. Brurberg

    发明人： Vincent G. H. Eijsink ,  Ingolf F. Nes ,  May B. Brurberg

    IPC分类号： C07H2104

    CPC分类号： C12N15/746 ,  C07K14/335

    摘要： The present invention concerns the discovery of a new regulatory mechanism for gene expression in lactic acid bacteria (LAB), especially Lactobacillus sake LTH673 or Lactobacillus plantarium C11, that includes previously unrecognized strongly regulable promoter elements. The essential finding is that the expression of genes under the control of a promoter element dependent on the expression of the IF-K-R gene cluster. The expression of the IF-K-R gene cluster is autoinduced by the secreted peptide encoded by IF, thus providing a regulable expression system for a desired protein. The invention further comprises the purified IF protein.

    摘要翻译： 本发明涉及发现乳酸菌（LAB）中的基因表达的新调控机制，特别是莱茵酸乳杆菌LTH673或植物乳杆菌C11，其包括先前未被认可的强调节的启动子元件。 基本发现是依赖于IF-K-R基因簇的表达的启动子元件控制下的基因的表达。 IF-K-R基因簇的表达由IF编码的分泌肽自动诱导，从而为所需蛋白提供可调节的表达系统。 本发明还包括纯化的IF蛋白。

    Tumor suppressor gene p33ING2
    9.
    发明授权
    Tumor suppressor gene p33ING2 失效
    肿瘤抑制基因p33ING2

    公开(公告)号：US06790948B1

    公开(公告)日：2004-09-14

    申请号：US09513365

    申请日：2000-02-25

    申请人： Curtis C. Harris ,  Makoto Nagashima

    发明人： Curtis C. Harris ,  Makoto Nagashima

    IPC分类号： C07H2104

    CPC分类号： C07H21/02 ,  C07H21/04 ,  C07K14/4703

    摘要： The invention provides isolated nucleic acid and amino acid sequences of novel human tumor suppressors, antibodies to such tumor suppressors, methods of detecting such nucleic acids and proteins, methods of screening for modulators of tumor suppressors, and methods of diagnosing and treating tumors with such nucleic acids and proteins.

    摘要翻译： 本发明提供了新型人肿瘤抑制基因的分离的核酸和氨基酸序列，这种肿瘤抑制基因的抗体，检测这种核酸和蛋白质的方法，筛选肿瘤抑制因子调节剂的方法，以及用这种核酸诊断和治疗肿瘤的方法 酸和蛋白质。