发明授权
- 专利标题: Process for the preparation of pyridine derivatives
- 专利标题(中): 吡啶衍生物的制备方法
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申请号: US09462180申请日: 2000-01-03
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公开(公告)号: US06313303B1公开(公告)日: 2001-11-06
- 发明人: Katsuya Tagami , Nobuo Niikawa , Akio Kayano , Hirofumi Kuroda
- 申请人: Katsuya Tagami , Nobuo Niikawa , Akio Kayano , Hirofumi Kuroda
- 优先权: JP9-186095 19970711; JP9-197119 19970723; JP10-117706 19980428
- 主分类号: C07D40100
- IPC分类号: C07D40100
摘要:
Processes for preparing sulfoxides useful as drugs such as acid secretion inhibitors or antiulcer drugs or intermediates for the preparation of drugs in high yields, at high purities, and with safety. Specifically, a process for the preparation of sulfoxides (II) by oxidizing a thio ether (I) with a peroxoborate salt in the presence of an acid anhydride or a metal catalyst; and a process for the preparation of sulfoxides (II) by oxidizing a thio ether (I) with an N-halosuccinimide, 1,3-dihalo-5,5-dimethyl-hydantoin or dichloroisocyanuric acid salt in the presence of a base. In said formulae R1 is hydrogen, methoxy or difluoromethoxy; R2 is methyl or methoxy; R3 is 3-methoxypropoxy, methoxy or 2,2,2-trifluoroethoxy; and R4 is hydrogen or methyl