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US06323041B1 Screening novel human phosphodiesterase IV isozymes for compounds which modify their enzymatic activity 失效
筛选出改变其酶活性的化合物的新型人类磷酸二酯酶IV同功酶

  • 专利标题： Screening novel human phosphodiesterase IV isozymes for compounds which modify their enzymatic activity
  • 专利标题（中）： 筛选出改变其酶活性的化合物的新型人类磷酸二酯酶IV同功酶
  • 申请号： US08472600
    申请日： 1995-06-07
  • 公开(公告)号： US06323041B1
    公开(公告)日： 2001-11-27
  • 发明人: Douglas A. Fisher , Michael D. Robbins
  • 申请人： Douglas A. Fisher , Michael D. Robbins
  • 主分类号： G01N33566
  • IPC分类号： G01N33566
Screening novel human phosphodiesterase IV isozymes for compounds which modify their enzymatic activity
摘要：
This invention relates to novel nucleic acid sequences encoding three novel human phosphodiesterase (hPDE IV) isozymes. It also relates to polypeptides encoded by such sequences. This invention also relates to an assay method for detecting the presence of such novel isozymes in human cells, and to a method of identifying compounds or other substances that inhibit or modify the activity of such isozymes.
摘要（中）：

本发明涉及编码三种新型人磷酸二酯酶（hPDE IV）同功酶的新型核酸序列。 它还涉及由这些序列编码的多肽。 本发明还涉及用于检测人细胞中这种新型同功酶的存在的测定方法，以及鉴定抑制或改变此类同功酶活性的化合物或其它物质的方法。

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