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    Human phosphodiesterase IV isozymes
    1.
    发明授权
    Human phosphodiesterase IV isozymes 失效
    人类磷酸二酯酶IV同功酶

    公开(公告)号：US06914133B2

    公开(公告)日：2005-07-05

    申请号：US10165135

    申请日：2002-06-06

    申请人： Douglas A. Fisher ,  Michael D. Robbins

    发明人： Douglas A. Fisher ,  Michael D. Robbins

    IPC分类号： C12N9/16 ,  C12Q1/34 ,  C07H21/02 ,  C12Q1/68

    CPC分类号： C12Q1/34 ,  C12N9/16 ,  G01N2500/00

    摘要： This invention relates to novel nucleic acid sequences encoding three novel human phosphodiesterase (hPDE IV) isozymes. It also relates to polypeptides encoded by such sequences.This invention also relates to an assay method for detecting the presence of such novel isozymes in human cells, and to a method of identifying compounds or other substances that inhibit or modify the activity of such isozymes.

    摘要翻译： 本发明涉及编码三种新型人磷酸二酯酶（hPDE IV）同功酶的新型核酸序列。 它还涉及由这些序列编码的多肽。 本发明还涉及用于检测人细胞中这种新型同功酶的存在的测定方法，以及鉴定抑制或改变此类同功酶活性的化合物或其它物质的方法。

    PACKAGING ASSEMBLY FOR AN OPTICAL CHIP IN A GYROSCOPIC UNIT
    2.
    发明申请
    PACKAGING ASSEMBLY FOR AN OPTICAL CHIP IN A GYROSCOPIC UNIT 审中-公开
    包装组件在光学单元中的光学芯片

    公开(公告)号：US20080285250A1

    公开(公告)日：2008-11-20

    申请号：US11749093

    申请日：2007-05-15

    申请人： Andrew W. Kaliszek ,  Derek T. Mead ,  Jason C. Grooms ,  Michael D. Robbins ,  Christopher S. Herman

    发明人： Andrew W. Kaliszek ,  Derek T. Mead ,  Jason C. Grooms ,  Michael D. Robbins ,  Christopher S. Herman

    IPC分类号： H05K7/00 ,  H05K13/04

    CPC分类号： G01C19/722 ,  Y10T29/49826

    摘要： A structural packaging assembly to support a multi-function optic chip or the like is mountable in a gyroscopic unit. An example assembly includes a housing mounted to a mounting plate. The chip is located in the housing, which in turn is coupled to a mounting plate. The housing may have a prescribed section modulus capable of sufficiently withstanding applied vibrations within a predefined vibrational range, such as a vibrational range at or below about 3500 Hz. The structural packaging assembly utilizes a mounting system with mounting feet that clamp to dowels, which in turn have been press fit into the mounting plate. In one embodiment, the mounting feet take the form of “C” clamp mechanisms, which after being clamped to the dowels, allow for resonance dampening between the housing and the mounting plate.

    摘要翻译： 用于支撑多功能光学芯片等的结构性封装组件可安装在陀螺仪单元中。 示例性组件包括安装到安装板的壳体。 芯片位于壳体中，壳体又连接到安装板。 壳体可以具有能够在预定的振动范围内充分承受施加的振动的规定截面模数，例如在约3500Hz以下的振动范围。 结构包装组件使用安装系统，其具有夹紧到销钉的安装脚，所述榫钉又被压配合到安装板中。 在一个实施例中，安装脚采取“C”夹紧机构的形式，其在夹紧到销钉之后允许壳体和安装板之间的共振阻尼。

    Screening novel human phosphodiesterase IV isozymes for compounds which modify their enzymatic activity
    4.
    发明授权
    Screening novel human phosphodiesterase IV isozymes for compounds which modify their enzymatic activity 失效
    筛选出改变其酶活性的化合物的新型人类磷酸二酯酶IV同功酶

    公开(公告)号：US06323041B1

    公开(公告)日：2001-11-27

    申请号：US08472600

    申请日：1995-06-07

    申请人： Douglas A. Fisher ,  Michael D. Robbins

    发明人： Douglas A. Fisher ,  Michael D. Robbins

    IPC分类号： G01N33566

    CPC分类号： C12Q1/34 ,  C12N9/16 ,  G01N2500/00

    摘要： This invention relates to novel nucleic acid sequences encoding three novel human phosphodiesterase (hPDE IV) isozymes. It also relates to polypeptides encoded by such sequences. This invention also relates to an assay method for detecting the presence of such novel isozymes in human cells, and to a method of identifying compounds or other substances that inhibit or modify the activity of such isozymes.

    摘要翻译： 本发明涉及编码三种新型人磷酸二酯酶（hPDE IV）同功酶的新型核酸序列。 它还涉及由这些序列编码的多肽。 本发明还涉及用于检测人细胞中这种新型同功酶的存在的测定方法，以及鉴定抑制或改变此类同功酶活性的化合物或其它物质的方法。

    Hybridization incubator with rotisserie mechanism
    6.
    发明授权
    Hybridization incubator with rotisserie mechanism 失效
    杂交培养箱与烤架机制

    公开(公告)号：US5380662A

    公开(公告)日：1995-01-10

    申请号：US531842

    申请日：1990-06-01

    申请人： Arthur J. Robbins ,  Michael D. Robbins

    发明人： Arthur J. Robbins ,  Michael D. Robbins

    IPC分类号： C12M1/10 ,  C12M3/04

    CPC分类号： B01F9/0021 ,  B01F9/002 ,  Y10S435/809

    摘要： A hybridization incubator assembly (10) is provided for incubation of samples contained in elongated sample bottles (16) and short sample bottles (60). The incubator (10) includes and oven body (18) which encloses a rotisserie assembly (14) adapted for carrying and agitating the sample bottles. The rotisserie assembly (14) includes a pair of bottle support wheels (43) mounted eccentrically on a drive shaft (40). The first wheel (44) and the second wheel (46) are mounted at different degrees of eccentricity and are axially separated on the drive shaft (40) by a distance slightly less than the length of the elongated bottles (16). Each support wheel (43) includes a plurality of grasping clamps (60) affixed about the rim portion (56) for holding the bottles (16), with each the grasping clamps (60) being paired with another on the opposing wheel (43) such that a bottle (16) may be supported by both wheels (43). The perimeter surface (58) of each wheel is beveled to facilitate agitation. The drive shaft (40) is caused to rotate by a drive motor (36) and a drive linkage (38) which cause the rotisserie assembly (14) to rotate about a rotational axis (41), thus transporting and agitating the samples within the oven cavity (28). The incubator (10) is primarily utilized for nucleotide hybridization procedures.

    摘要翻译： 提供了用于孵育细长样品瓶（16）和短样品瓶（60）中的样品的杂交培养箱组件（10）。 培养箱（10）和烘箱主体（18），其包围适于携带并搅拌样品瓶的旋转栅栏组件（14）。 旋转烤架组件（14）包括偏心地安装在驱动轴（40）上的一对瓶支撑轮（43）。 第一轮（44）和第二轮（46）以不同的偏心度安装，并且在驱动轴（40）上轴向分开比细长瓶（16）的长度稍短的距离。 每个支撑轮（43）包括围绕边缘部分（56）固定的多个抓持夹具（60），用于保持瓶子（16），每个夹持夹具（60）与相对的轮子（43）上的另一个配对， 使得瓶子（16）可以由两个轮子（43）支撑。 每个车轮的周边表面（58）是倾斜的以便于搅动。 通过驱动马达（36）和驱动联动装置（38）使驱动轴（40）旋转，导致旋转式烤架组件（14）围绕旋转轴线（41）转动，从而将样品传送和搅拌 烤箱腔（28）。 培养箱（10）主要用于核苷酸杂交程序。

    Human phosphodiesterase IV isozymes
    7.
    发明授权
    Human phosphodiesterase IV isozymes 失效
    人类磷酸二酯酶IV同功酶

    公开(公告)号：US07087734B2

    公开(公告)日：2006-08-08

    申请号：US10704447

    申请日：2003-11-07

    申请人： Douglas A. Fisher ,  Michael D. Robbins

    发明人： Douglas A. Fisher ,  Michael D. Robbins

    IPC分类号： C07H21/02 ,  C12Q1/68

    CPC分类号： C12Q1/34 ,  C12N9/16 ,  G01N2500/00

    摘要： This invention relates to novel nucleic acid sequences encoding three novel human phosphodiesterase (hPDE IV) isozymes. It also relates to polypeptides encoded by such sequences.This invention also relates to an assay method for detecting the presence of such novel isozymes in human cells, and to a method of identifying compounds or other substances that inhibit or modify the activity of such isozymes.

    摘要翻译： 本发明涉及编码三种新型人磷酸二酯酶（hPDE IV）同功酶的新型核酸序列。 它还涉及由这些序列编码的多肽。 本发明还涉及用于检测人细胞中这种新型同功酶的存在的测定方法，以及鉴定抑制或改变此类同功酶活性的化合物或其它物质的方法。

    Automatic wafer edge inspection and review system
    10.
    发明授权
    Automatic wafer edge inspection and review system 失效
    自动晶圆边缘检查和审查系统

    公开(公告)号：US07508504B2

    公开(公告)日：2009-03-24

    申请号：US11891657

    申请日：2007-08-09

    申请人： Ju Jin ,  Satish Sadam ,  Vishal Verma ,  Zhiyan Huang ,  Siming Lin ,  Michael D Robbins ,  Paul F. Forderhase

    发明人： Ju Jin ,  Satish Sadam ,  Vishal Verma ,  Zhiyan Huang ,  Siming Lin ,  Michael D Robbins ,  Paul F. Forderhase

    IPC分类号： G01N21/00

    CPC分类号： G01N21/4738 ,  G01N21/9503

    摘要： A substrate illumination and inspection system provides for illuminating and inspecting a substrate particularly the substrate edge. The system uses a light diffuser with a plurality of lights disposed at its exterior or interior for providing uniform diffuse illumination of a substrate. An optic and imaging system exterior of the light diffuser are used to inspect the plurality of surfaces of the substrate including specular surfaces. The optic can be rotated radially relative to a center point of the substrate edge to allow for focused inspection of all surfaces of the substrate edge.

    摘要翻译： 衬底照明和检查系统提供用于照明和检查衬底，特别是衬底边缘。 该系统使用具有设置在其外部或内部的多个光的光漫射器，用于提供衬底的均匀漫射照明。 光扩散器的光学和成像系统外部用于检查包括镜面的基板的多个表面。 光学元件可以相对于基板边缘的中心点径向旋转，以允许对基板边缘的所有表面进行聚焦检查。