发明授权
- 专利标题: Dolastatin peptides
- 专利标题(中): Dolastatin肽
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申请号: US09539935申请日: 2000-03-31
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公开(公告)号: US06323315B1公开(公告)日: 2001-11-27
- 发明人: George R. Pettit , Jayaram K. Srirangam , Michael D. Williams , Kieran P. M. Durkin , Teresa Barlozzari , Andreas Kling , Bernd Janssen , Andreas Haupt
- 申请人: George R. Pettit , Jayaram K. Srirangam , Michael D. Williams , Kieran P. M. Durkin , Teresa Barlozzari , Andreas Kling , Bernd Janssen , Andreas Haupt
- 主分类号: C07D20709
- IPC分类号: C07D20709
摘要:
The present invention provides compounds of the formula where R1-R5 are each, independently, a hydrogen atom or a normal or branched C1-C6-alkyl group; A is a methionyl, phenylalanyl or phenylglycyl residue; n is 0 or 1; R6 is a hydrogen atom; and R7 is a carbocylic group, an aromatic group, a C1-C4-alkyl group, a pyridylalkyl group or a heterocyclic group. In another embodiment, R6 is benzyl or —C(O)OR8, where R8 is a C1-C6-alkyl group, and R7 is a heteroaromatic group, such as a 2-thiazolyl group.
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