发明授权
US06329148B1 Combined therapy of diterpenoid triepoxides and death domain receptor ligands for synergistic killing of tumor cells
失效
联合治疗二萜类三环氧化物和死亡域受体配体对肿瘤细胞的协同杀伤
- 专利标题： Combined therapy of diterpenoid triepoxides and death domain receptor ligands for synergistic killing of tumor cells
- 专利标题（中）： 联合治疗二萜类三环氧化物和死亡域受体配体对肿瘤细胞的协同杀伤
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申请号： US09505250申请日： 2000-02-15
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公开(公告)号： US06329148B1公开(公告)日： 2001-12-11
- 发明人: Glenn D. Rosen , Peter Kao
- 申请人： Glenn D. Rosen , Peter Kao
- 主分类号： C12Q168
- IPC分类号： C12Q168
摘要：
A synergistic combination of ligands that interact with death domain receptors, and diterpenoid triepoxides is used to increase tumor cell killing by induction of apoptosis. Ligands useful in the invention include TRAIL, TNF-&agr;, analogs thereof, stabilized multimers thereof, mimetics, etc. Of particular interest are combined therapy with the diterpenoid triepoxides triptolide and derivatives and analogs thereof.
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