Invention Grant
US06335342B1 Azaindole derivatives, process for their preparation, and their use as antitumor agents
失效
Azaindole衍生物,其制备方法及其作为抗肿瘤剂的用途
- Patent Title: Azaindole derivatives, process for their preparation, and their use as antitumor agents
- Patent Title (中): Azaindole衍生物,其制备方法及其作为抗肿瘤剂的用途
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Application No.: US09597274Application Date: 2000-06-19
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Publication No.: US06335342B1Publication Date: 2002-01-01
- Inventor: Antonio Longo , Maria Gabriella Brasca , Paolo Orsini , Gabriella Traquandi , Valeria Pittalà , Anna Vulpetti , Mario Varasi , Paolo Pevarello
- Applicant: Antonio Longo , Maria Gabriella Brasca , Paolo Orsini , Gabriella Traquandi , Valeria Pittalà , Anna Vulpetti , Mario Varasi , Paolo Pevarello
- Main IPC: A61K41435
- IPC: A61K41435

Abstract:
Novel 1H-pyrrolo[2,3-b]pyridines which are represented by formula (I): wherein R is a hydrogen or halogen atom or a group selected from —CN, —OH, —OCOR4, —(CH2)nNH2, —(CH2)nNHR4, —(CH2)nNHCOR4, —(CH2)nNHCONR4R5, —(CH2)nNHCOOR4, or —(CH2)nNHSO2R4, wherein n is either 0 or 1, R4 and R5 are as described in the specification; R1 is hydrogen or an optionally substituted alkyl group; R2 is an optionally substituted group selected from alkyl or aryl; R3 is hydrogen or a group selected from —CONR4R5, —COOR4, —CONHOR4, —SO2NHR4, alkylsulphonylaminocarbonyl or perfluorinated alkylsulphonylaminocarbonyl; or a pharmaceutically acceptable salt thereof, are disclosed. These compounds are useful for treating cell proliferative disorders associated with an altered cell dependent kinase activity.
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