发明授权
- 专利标题： Substituted 2(2,6-dioxopiperidin-3-yl)isoindolines
- 专利标题（中）： 取代的2（2,6-二氧代哌啶-3-基）异吲哚啉
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申请号： US09716528申请日： 2000-11-20
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公开(公告)号： US06335349B1公开(公告)日： 2002-01-01
- 发明人: George W. Muller , David I. Stirling , Roger Shen-Chu Chen
- 申请人： George W. Muller , David I. Stirling , Roger Shen-Chu Chen
- 主分类号： A61K31454
- IPC分类号： A61K31454
摘要：
Substituted 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindolines and 1-oxo-2-(2,6-dioxo-piperidin-3-yl)isoindolines reduce the levels of TNF&agr; in a mammal and are useful in treating oncogenic conditions, inflammation, and autoimmune diseases. Typical embodiments are 1-oxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4,5,6,7-tetrafluoroiso-indoline and 1,3-dioxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4-aminoisoindoline.
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