发明授权
- 专利标题: Compositions and methods for the treatment and diagnosis of cardiovascular disease
- 专利标题(中): 用于治疗和诊断心血管疾病的组合物和方法
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申请号: US09288292申请日: 1999-04-08
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公开(公告)号: US06359194B1公开(公告)日: 2002-03-19
- 发明人: Katherine Galvin , Dean A. Falb , Michael J. Donovan , Dennis Huszar , Michael A. Gimbrone, Jr.
- 申请人: Katherine Galvin , Dean A. Falb , Michael J. Donovan , Dennis Huszar , Michael A. Gimbrone, Jr.
- 主分类号: A01K67027
- IPC分类号: A01K67027
摘要:
The present invention is based on the generation and phenotypic characterization of transgenic knockout homozygous rchd534 mutant mice which display characteristic cardiovascular disease symptoms. Such transgenic knockout homozygous rchd534 mutant mice are useful models for the analysis and characterization of rchd534 protein involvement in development and homeostasis of the cardiovascular system and tissue-specific regulation of the TGF-&bgr; signaling pathways. Such transgenic mice may be used for screening compounds that may potentially useful for treating or preventing cardiovascular disease.
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