发明授权
- 专利标题： Farnesyl protein transferase inhibitors
- 专利标题（中）： 法呢基蛋白转移酶抑制剂
-
申请号： US09465523申请日： 1999-12-16
-
公开(公告)号： US06362188B1公开(公告)日： 2002-03-26
- 发明人: Timothy Guzi , Dinanath F. Rane , Alan K. Mallams , Alan B. Cooper , Ronald J. Doll , Viyyoor M. Girijavallabhan , Arthur G. Taveras , Corey Strickland , Joseph M. Kelly , Jianping Chao
- 申请人： Timothy Guzi , Dinanath F. Rane , Alan K. Mallams , Alan B. Cooper , Ronald J. Doll , Viyyoor M. Girijavallabhan , Arthur G. Taveras , Corey Strickland , Joseph M. Kelly , Jianping Chao
- 主分类号： A61K31496
- IPC分类号： A61K31496
摘要：
Disclosed are compounds of the formula: wherein R8 represents a cyclic moiety to which is bound an imodazolylalkyl group; R9 represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.