Apparatus and methods are provided for forming a channel in an organ or vessel to enhance perfusion therein. The apparatus may include a bioactive agent to stimulate tissue growth and vascularization in tissue adjacent to the channel. The apparatus includes a stent, suitable for percutaneous or intraoperative placement, that includes a tubular member having a plurality of tines, barbs, ribs or other structure to secure the stent at a desired position within tissue.