发明授权
US06365711B1 Methods and reagents for modulating TGF-&bgr; superfamily signalling
失效
用于调节TGF-β超家族信号传导的方法和试剂
- 专利标题： Methods and reagents for modulating TGF-&bgr; superfamily signalling
- 专利标题（中）： 用于调节TGF-β超家族信号传导的方法和试剂
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申请号： US09087134申请日： 1998-05-28
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公开(公告)号： US06365711B1公开(公告)日： 2002-04-02
- 发明人: Malcolm Whitman , Xin Chen
- 申请人： Malcolm Whitman , Xin Chen
- 主分类号： C07K1447
- IPC分类号： C07K1447
摘要：
FAST-1 and Smad2 or Smad3 form a complex that is specifically induced by signals generated by a TGF-&bgr; superfamily member. We have shown that a domain of FAST-1 directly interacts with Smad2 or Smad3, and that this interaction is mediated by specific domains of the two interacting molecules, namely, the MH2 domain of Smad2 or Smad3 and the Smad Interaction Domain (SID) of FAST-1. This result allows the development of methods and reagents for the isolation of compounds that are involved in, and/or modulate, TGF-&bgr; superfamily signalling.
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