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52 条记录 (耗时 0.028 秒)

    Density enhanced protein tyrosine phosphatases
    2.
    发明授权
    Density enhanced protein tyrosine phosphatases 失效
    密度增强蛋白酪氨酸磷酸酶

    公开(公告)号：US06552169B1

    公开(公告)日：2003-04-22

    申请号：US09447533

    申请日：1999-11-23

    申请人： Nicholas K. Tonks ,  Arne Ostman

    发明人： Nicholas K. Tonks ,  Arne Ostman

    IPC分类号： C07K1447

    CPC分类号： C07K16/40 ,  A61K38/00 ,  C12N9/16 ,  C12Q1/42 ,  G01N33/573

    摘要： Novel Type III density enhanced protein tyrosine phosphatases are disclosed and exemplified by human DEP-1 enzyme. Polynucleotides encoding huDEP-1 are disclosed, along with methods and materials for production of the same by recombinant procedures. Binding molecules specific for DEP-1 are also disclosed as useful for modulating the biological activities of DEP-1.

    摘要翻译： 新型III型密度增强蛋白酪氨酸磷酸酶由人DEP-1酶公开和示例。 公开了编码huDEP-1的多核苷酸，以及通过重组程序生产其的方法和材料。 还公开了对DEP-1特异性的结合分子可用于调节DEP-1的生物活性。

    Intracellular vitamin D binding protein
    4.
    发明授权
    Intracellular vitamin D binding protein 失效
    细胞内维生素D结合蛋白

    公开(公告)号：US06268478B1

    公开(公告)日：2001-07-31

    申请号：US08797358

    申请日：1997-02-11

    申请人： John S. Adams

    发明人： John S. Adams

    IPC分类号： C07K1447

    CPC分类号： C07K14/57 ,  A61K38/00

    摘要： The invention relates to the discovery and purification of novel intracellular vitamin D binding proteins (IDBPs) and the isolation of polynucleotide sequences encoding the proteins. IDBPs are of interest because they mediate the vitamin D resistance, i.e., insensitivity, observed in new world primates. IDBPs are distinct from the vitamin D receptor and other intracellular receptors, e.g. estrogen receptor. One aspect of the invention is to provide purified IDBPs as pharmaceutical compositions to affect steroid hormone activity. Another aspect of the invention provides polynucleotides encoding the IDBPs of the invention for use in altering the expression of IDBPs. Yet another aspect of the invention is to provide assays for the detection or screening of therapeutic compounds that interfere with the interaction between IDBP and vitamin D (or other ligands that bind to IDBP), and the use of such compounds as pharmaceutical compositions.

    摘要翻译： 本发明涉及新型细胞内维生素D结合蛋白（IDBPs）的发现和纯化以及编码蛋白质的多核苷酸序列的分离。 IDBPs是有意义的，因为它们介导在新世界灵长类动物中观察到的维生素D抗性，即不敏感性。 IDBPs不同于维生素D受体和其他细胞内受体，例如。 雌激素受体。 本发明的一个方面是提供纯化的IDBPs作为影响类固醇激素活性的药物组合物。 本发明的另一方面提供编码本发明的IDBPs的多核苷酸，用于改变IDBP的表达。 本发明的另一方面是提供用于检测或筛选干扰IDBP和维生素D（或与IDBP结合的其它配体）之间的相互作用的治疗化合物的测定，以及使用这些化合物作为药物组合物。

    Polypeptides their production and use
    5.
    发明授权
    Polypeptides their production and use 失效
    多肽的生产和使用

    公开(公告)号：US06228984B1

    公开(公告)日：2001-05-08

    申请号：US08776971

    申请日：1997-02-07

    申请人： Shuji Hinuma ,  Yugo Habata ,  Yuji Kawamata ,  Masaki Hosoya ,  Ryo Fujii ,  Shoji Fukusumi ,  Chieko Kitada

    发明人： Shuji Hinuma ,  Yugo Habata ,  Yuji Kawamata ,  Masaki Hosoya ,  Ryo Fujii ,  Shoji Fukusumi ,  Chieko Kitada

    IPC分类号： C07K1447

    CPC分类号： C07H21/04 ,  A61K38/00 ,  C07K14/575 ,  C07K14/705 ,  C07K14/72 ,  C07K16/28

    摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervous system function modulators, and pancreatic function modulators, and (2) development of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.

    摘要翻译： 本发明涉及用于人垂体和小鼠胰腺衍生的G蛋白偶联受体蛋白质的配体多肽。 编码配体多肽的配体多肽或DNA可用于（1）开发药物如垂体功能调节剂，中枢神经系统功能调节剂和胰腺功能调节剂，以及（2）重组受体蛋白的发育和筛选 的药物候选化合物。 特别地，通过利用根据本发明的重组G蛋白偶联受体蛋白表达的受体结合测定系统，可以筛选对人类和其他温血动物特异性的G蛋白偶联受体的激动剂和拮抗剂， 获得的激动剂或拮抗剂可用作各种疾病的治疗和预防剂。

    FADD-like anti-apoptotic molecules, methods of using the same, and compositions for and methods of making the same
    6.
    发明授权
    FADD-like anti-apoptotic molecules, methods of using the same, and compositions for and methods of making the same 有权
    FADD样抗凋亡分子，其使用方法，组合物及其制备方法

    公开(公告)号：US06207801B1

    公开(公告)日：2001-03-27

    申请号：US09276993

    申请日：1999-03-26

    申请人： Emad S. Alnemri

    发明人： Emad S. Alnemri

    IPC分类号： C07K1447

    CPC分类号： B82Y30/00 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4747

    摘要： Two FADD-like anti-apoptotic proteins that regulate Fas/TNFR1- or UV-induced apoptosis are disclosed. Nucleotide sequences encoding the proteins are disclosed as are methods of using the nucleic acid molecules and making the proteins. Pharmaceutical compositions and methods of using the same are disclosed. Reagents, kits and methods of identifying compounds that inhibit anti-apoptotic activity of the proteins and methods of identifying compounds that inhibit binding activity of the proteins are disclosed.

    摘要翻译： 公开了调节Fas / TNFR1或UV诱导的凋亡的两种FADD样抗凋亡蛋白。 公开了编码蛋白质的核苷酸序列，作为使用核酸分子和制备蛋白质的方法。 公开了药物组合物及其使用方法。 公开了鉴定抑制蛋白质的抗凋亡活性的化合物的试剂，试剂盒和方法以及鉴定抑制蛋白质结合活性的化合物的方法。

    Mast cell-specific signal transducing molecules and cDNAs thereof
    7.
    发明授权
    Mast cell-specific signal transducing molecules and cDNAs thereof 失效
    肥大细胞特异性信号转导分子及其cDNA

    公开(公告)号：US06831151B1

    公开(公告)日：2004-12-14

    申请号：US09856061

    申请日：2001-07-10

    申请人： Ryo Goitsuka

    发明人： Ryo Goitsuka

    IPC分类号： C07K1447

    CPC分类号： C07K14/47

    摘要： The present invention provides a signal transducer specifically expressed in mouse mast cells that has the amino acid sequence of SEQ ID No. 2, a signal transducer specifically expressed in human mast cells that has the amino acid sequence of SEQ ID No. 4, polynucleotides encoding these proteins, an expression vector involving these polynucleotides, transformed cells induced by these expression vectors, and antibodies against the foregoing proteins. The signal transducer provided in the present invention is useful for screening of novel medicines against allergic diseases.

    摘要翻译： 本发明提供了特异性表达于具有SEQ ID No.2的氨基酸序列的小鼠肥大细胞中的信号转导体，特异性表达于具有SEQ ID No.4的氨基酸序列的人肥大细胞中的信号转导体，编码 这些蛋白质，涉及这些多核苷酸的表达载体，由这些表达载体诱导的转化细胞，以及针对上述蛋白质的抗体。 本发明提供的信号转导体可用于筛选抗过敏性疾病的新型药物。

    Binding protein
    8.
    发明授权
    Binding protein 失效
    结合蛋白

    公开(公告)号：US06777538B2

    公开(公告)日：2004-08-17

    申请号：US09755251

    申请日：2001-01-05

    申请人： Sergio Abrignani

    发明人： Sergio Abrignani

    IPC分类号： C07K1447

    CPC分类号： G01N33/56983 ,  C07K14/705 ,  G01N33/5767 ,  G01N2333/18 ,  G01N2333/705 ,  G01N2469/20

    摘要： A 24 kd protein capable of binding the E2 envelope protein of hepatitis C virus (HCV), and functionally equivalent variants or fragments of the 24 kd protein, are disclosed. Processes for production and purification of the 24 kd protein, and functionally equivalent variants or fragments thereof, are also disclosed.

    摘要翻译： 公开了能够结合丙型肝炎病毒（HCV）的E2包膜蛋白和24kd蛋白的功能等同变体或片段的24kd蛋白质。 还公开了24kd蛋白质的生产和纯化方法及其功能上等同的变体或片段。