发明授权
- 专利标题: Intermediates useful for the manufacture of carbapenem and a stereoselective manufacturing method therefor
- 专利标题(中): 可用于制造碳青霉烯类的中间体及其立体选择性制造方法
-
申请号: US09705183申请日: 2000-11-02
-
公开(公告)号: US06372914B1公开(公告)日: 2002-04-16
- 发明人: Takaaki Suzuki , Isao Sugiyama , Manabu Sasho , Nobuaki Sato , Atsushi Kamada , Kazuhide Ashizawa
- 申请人: Takaaki Suzuki , Isao Sugiyama , Manabu Sasho , Nobuaki Sato , Atsushi Kamada , Kazuhide Ashizawa
- 优先权: JP9-133171 19970523
- 主分类号: C07D26318
- IPC分类号: C07D26318
摘要:
The present invention provides an efficient stereoselective method for manufacturing (2S,4S)-2-[[(R)-hydroxy-(3R)-cyclic amine-3-yl]methyl]pyrrolidine-4-thiol or a salt thereof which is useful as an intermediate for the manufacture of carbapenem and also provides the intermediate. A method for manufacturing which comprises the step of reacting a compound of the formula (I): (wherein, R1 is a lower alkylsulfonyl group, an optionally substituted arylsulfonyl group or an alkylsilyl group; and R2 is a protecting group for an amino group) with a compound of the formula (II): (wherein, R3 is a substituted or unsubstituted lower alkyl group or aryl group; X is an oxygen atom or a sulfur atom; Y is an azide group or a nitro group; and m is an integer of 2 to 5).
信息查询