发明授权
US06372914B1 Intermediates useful for the manufacture of carbapenem and a stereoselective manufacturing method therefor 失效
可用于制造碳青霉烯类的中间体及其立体选择性制造方法

Intermediates useful for the manufacture of carbapenem and a stereoselective manufacturing method therefor
摘要:
The present invention provides an efficient stereoselective method for manufacturing (2S,4S)-2-[[(R)-hydroxy-(3R)-cyclic amine-3-yl]methyl]pyrrolidine-4-thiol or a salt thereof which is useful as an intermediate for the manufacture of carbapenem and also provides the intermediate. A method for manufacturing which comprises the step of reacting a compound of the formula (I): (wherein, R1 is a lower alkylsulfonyl group, an optionally substituted arylsulfonyl group or an alkylsilyl group; and R2 is a protecting group for an amino group) with a compound of the formula (II): (wherein, R3 is a substituted or unsubstituted lower alkyl group or aryl group; X is an oxygen atom or a sulfur atom; Y is an azide group or a nitro group; and m is an integer of 2 to 5).
信息查询
0/0