发明授权
- 专利标题： Labelled elastase inhibitors
- 专利标题（中）： 标记弹性蛋白酶抑制剂
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申请号： US09254541申请日： 2000-05-16
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公开(公告)号： US06375926B1公开(公告)日： 2002-04-23
- 发明人: Karen Jane Barnes , Gary Robert Bower , Alan Michael Forster , Peter Knox , Marivi Mendizabal , Anthony Eamon Storey
- 申请人： Karen Jane Barnes , Gary Robert Bower , Alan Michael Forster , Peter Knox , Marivi Mendizabal , Anthony Eamon Storey
- 优先权： EP96306718 19960916
- 主分类号： A61K5100
- IPC分类号： A61K5100
摘要：
A human leucocyte elastase (HLE) inhibitor labelled with a detector moiety where the inhibitor is synthetic and has a molecular weight of less than 2000, is useful for the diagnostic imaging of sites of inflammation of infection in vivo, for labelling leucocytes in vitro, or for radiotherapy of rthritis. The HLE inhibitor is preferably a &bgr;-lactam or an azetidinone.
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