发明授权
US06384075B1 Bicyclic amino derivatives and PGD2, antagonist containing them
失效
双环氨基衍生物和PGD2，含有它们的拮抗剂
- 专利标题： Bicyclic amino derivatives and PGD2, antagonist containing them
- 专利标题（中）： 双环氨基衍生物和PGD2，含有它们的拮抗剂
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申请号： US09506608申请日： 2000-02-18
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公开(公告)号： US06384075B1公开(公告)日： 2002-05-07
- 发明人: Mitsuaki Ohtani , Akinori Arimura , Tatsuo Tsuri , Junji Kishino , Tsunetoshi Honma
- 申请人： Mitsuaki Ohtani , Akinori Arimura , Tatsuo Tsuri , Junji Kishino , Tsunetoshi Honma
- 优先权： JP7-154575 19950621
- 主分类号： A61K31557
- IPC分类号： A61K31557
摘要：
A compound of the formula (I): wherein: for example, a compound below: wherein: R1 is CH3, H or Na; and X1—X2—X3 is: or its salt or a hydrate thereof is useful as PGD2 antagonist and can be used as a drug for treating diseases in which mast cell dysfunction is involved, for example, systemic mastocytosis and disorder of systemic mast cell activation, and also tracheal contraction, asthma, allergic rhinitis, allergic conjunctivitis, urticaria, injury due to ischemic reperfusion, and as an anti-inflammatory agent. It is particularly useful in the treatment of nasal occlusion.
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