发明授权
- 专利标题： Process for producing benzothiophenecarboxylic acid amide derivatives
- 专利标题（中）： 苯并噻吩羧酸酰胺衍生物的制备方法
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申请号： US09647353申请日： 2000-09-29
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公开(公告)号： US06399788B1公开(公告)日： 2002-06-04
- 发明人: Tsunetoshi Honma , Yoshiharu Hiramatsu , Tetsuo Okada , Makoto Kakinuma
- 申请人： Tsunetoshi Honma , Yoshiharu Hiramatsu , Tetsuo Okada , Makoto Kakinuma
- 优先权： JP10-087311 19980331
- 主分类号： C07D33364
- IPC分类号： C07D33364
摘要：
A process for preparing a compound having PGD2 antagonism represented by the formula (I), or a pharmaceutically acceptable salt or hydrate thereof, which process comprises reacting an amino alcohol of the formula (II) or its salt with a compound of the formula (III) or its reactive derivative, oxidizing the product with halo oxoacid in the presence of 2,2,6,6-tetramethylpiperidine-1-oxyls, reacting the product with an ylide under the conditions for Wittig reaction, and optionally deprotecting the product.
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