发明授权
- 专利标题: Thienopyridine derivatives and their use
- 专利标题(中): 噻吩并吡啶衍生物及其用途
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申请号: US09506010申请日: 2000-02-17
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公开(公告)号: US06403606B1公开(公告)日: 2002-06-11
- 发明人: Takashi Sohda , Haruhiko Makino , Atsuo Baba
- 申请人: Takashi Sohda , Haruhiko Makino , Atsuo Baba
- 优先权: JP8-105916 19960425; JP8-105917 19960425
- 主分类号: A61K314353
- IPC分类号: A61K314353
摘要:
There is disclosed a compound of the formula (A): wherein W is C—G or C—G′ (G is optionally esterified carboxyl; and G′ is halogen); X is oxygen, optionally oxidized sulfur or —(CH2)q—, (q is 0 to 5); R is optionally substituted amino or heterocyclic group; the ring B is optionally substituted nitrogen-containing 5- to 7-membered ring; L is hydrogen, optionally substituted hydrocarbon residue, optionally substituted acyl, optionally substituted carbamoyl, optionally substituted thiocarbamoyl or optionally substituted sulfonyl provided that, when W is C—G, L is hydrogen, optionally substituted acyl, optionally substituted carbamoyl, optionally substituted alkoxycarbonyl, optionally substituted thiocarbamoyl or optionally substituted sulfonyl; n is 0 or 1; the ring A may have a substituent. A process for producing the compound (A) and a pharmaceutical composition containing the compound (A) are also disclosed. The pharmaceutical composition is useful for an anti-inflammatory drug, particularly, a drug for preventing or treating arthritis, a drug for inhibiting bone resorption, immunosuppressant or the like.
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