An audio information bit stream including audio control bits and audio data bits is processed for transmission in a communication system. The audio data bits are first separated into n classes based on error sensitivity, that is, the impact of errors in particular audio data bits on perceived quality of an audio signal reconstructed from the transmission. Each of the n different classes of audio data bits is then provided with a corresponding one of n different levels of error protection, where n is greater than or equal to two. The invention thereby matches error protection for the audio data bits to source and channel error sensitivity. The audio control bits may be transmitted independently of the audio data bits, using an additional level of error protection higher than that used for any of the n classes of the audio data bits. Alternatively, the control bits may be combined with one of the n classes of audio data bits and provided with the highest of the n levels of error protection. Further protection may be provided for the control bits by repeating at least a portion of the control bits from a current packet of the audio information bit stream in a subsequent packet of the audio information bit stream. Moreover, the classification of audio data bits into n different classes can be implemented on a fixed packet-by-packet basis, or in a more flexible, adaptive implementation in which different multipacket error protection profiles are used for different multipacket segments of a source-coded audio signal.