发明授权
- 专利标题: Secreted proteins and uses thereof
- 专利标题(中): 分泌蛋白及其用途
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申请号: US09336536申请日: 1999-06-18
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公开(公告)号: US06406884B1公开(公告)日: 2002-06-18
- 发明人: Steven Bossone
- 申请人: Steven Bossone
- 主分类号: C12P2102
- IPC分类号: C12P2102
摘要:
The invention provides isolated nucleic acid molecules, designated TANGO 281, which encode proteins downregulated in megakaryocytes that fail to express the gata-1 transcription factor (a factor critical for blood cell formulation) and can, therefore, represent direct or indirect gata-1 targets. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic polypeptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.