发明授权
US06407241B1 Process and intermediates for the preparation of imidazolidinone &agr;v integrin antagonists
失效
用于制备咪唑啉酮阿拉夫综合素拮抗剂的方法和中间体
- 专利标题： Process and intermediates for the preparation of imidazolidinone &agr;v integrin antagonists
- 专利标题（中）： 用于制备咪唑啉酮阿拉夫综合素拮抗剂的方法和中间体
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申请号： US09707403申请日： 2000-11-07
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公开(公告)号： US06407241B1公开(公告)日： 2002-06-18
- 发明人: Mark S Jensen , Michael Palucki , Nelo R. Rivera , Kenneth M. Wells , Yi Xiao , Yaling Wang , Chunhua Yang , Nobuyoshi Yasuda
- 申请人： Mark S Jensen , Michael Palucki , Nelo R. Rivera , Kenneth M. Wells , Yi Xiao , Yaling Wang , Chunhua Yang , Nobuyoshi Yasuda
- 主分类号： C07D47104
- IPC分类号： C07D47104
摘要：
A novel process is provided for the preparation of imidazolidinone &agr;v&bgr;3/&agr;v&bgr;5 integrin antagonists, and the useful intermediates obtained therein. These compounds are antagonists of &agr;v&bgr;3/&agr;v&bgr;5 integrin receptors and thus useful for inhibiting bone resorption and treating and preventing osteoporosis. Also disclosed is 3-{2-oxo-3-[3-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-propyl]imidazolidin-1-yl}-3(S)-(6-methoxy-pyridin-3-yl)-propionic acid in the form of a hemihydrate.
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