发明授权
US06413995B1 Cinnamamide derivatives and drug compositions containing the same
失效
肉桂酰胺衍生物和含有它们的药物组合物
- 专利标题: Cinnamamide derivatives and drug compositions containing the same
- 专利标题(中): 肉桂酰胺衍生物和含有它们的药物组合物
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申请号: US09856419申请日: 2001-05-21
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公开(公告)号: US06413995B1公开(公告)日: 2002-07-02
- 发明人: Yoshihiro Hasegawa , Shouichirou Shindou , Tomohisa Hattori , Tatsuhiro Obata , Fumiko Horiuchi , Hiroyuki Hayakawa , Hiroaki Kumazawa
- 申请人: Yoshihiro Hasegawa , Shouichirou Shindou , Tomohisa Hattori , Tatsuhiro Obata , Fumiko Horiuchi , Hiroyuki Hayakawa , Hiroaki Kumazawa
- 优先权: JP11-004384 19990111
- 主分类号: C07D21340
- IPC分类号: C07D21340
摘要:
The invention relates to cinnamamide derivatives having the following formula wherein R1 represents a hydroxyl group, a C1-6-alkoxy group, an arylalkoxy group or a substituted or unsubstituted amino group; R2 and R3 are same or different, each of which represents a hydrogen atom, a halogen atom or a C1-4-alkyl group; R4 represents a hydrogen atom or a C1-6-alkyl group; R5 represents a hydrogen atom, a C1-6-alkyl group or an aryl group; R6 represents a hydrogen atom, a C1-6-alkyl group, a cyano group or a C1-6-alkoxy-carbonyl group; W represents an oxygen atom, a sulfur atom, an imino group, a methylene group, a hydroxymethylene group or a carbonyl group; X and Y are same or different, each of which represents an oxygen atom or a sulfur atom; m represents an integer of 0 to 2; n represents an integer of 1 to 3; and when m is 0, a group: —C(R2)(R3)—W— may represent a vinylene group; or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing the above compound, in particular, an immunomodulatory agent and a prophylactic or therapeutic agent for nephrotic syndrome, circulatory disorders or respiratory diseases.