利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

26 条记录 (耗时 0.03 秒)

    Cinnamamide derivatives and drug compositions containing the same
    1.
    发明授权
    Cinnamamide derivatives and drug compositions containing the same 失效
    肉桂酰胺衍生物和含有它们的药物组合物

    公开(公告)号：US06413995B1

    公开(公告)日：2002-07-02

    申请号：US09856419

    申请日：2001-05-21

    申请人： Yoshihiro Hasegawa ,  Shouichirou Shindou ,  Tomohisa Hattori ,  Tatsuhiro Obata ,  Fumiko Horiuchi ,  Hiroyuki Hayakawa ,  Hiroaki Kumazawa

    发明人： Yoshihiro Hasegawa ,  Shouichirou Shindou ,  Tomohisa Hattori ,  Tatsuhiro Obata ,  Fumiko Horiuchi ,  Hiroyuki Hayakawa ,  Hiroaki Kumazawa

    IPC分类号： C07D21340

    CPC分类号： C07D213/40

    摘要： The invention relates to cinnamamide derivatives having the following formula wherein R1 represents a hydroxyl group, a C1-6-alkoxy group, an arylalkoxy group or a substituted or unsubstituted amino group; R2 and R3 are same or different, each of which represents a hydrogen atom, a halogen atom or a C1-4-alkyl group; R4 represents a hydrogen atom or a C1-6-alkyl group; R5 represents a hydrogen atom, a C1-6-alkyl group or an aryl group; R6 represents a hydrogen atom, a C1-6-alkyl group, a cyano group or a C1-6-alkoxy-carbonyl group; W represents an oxygen atom, a sulfur atom, an imino group, a methylene group, a hydroxymethylene group or a carbonyl group; X and Y are same or different, each of which represents an oxygen atom or a sulfur atom; m represents an integer of 0 to 2; n represents an integer of 1 to 3; and when m is 0, a group: —C(R2)(R3)—W— may represent a vinylene group; or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing the above compound, in particular, an immunomodulatory agent and a prophylactic or therapeutic agent for nephrotic syndrome, circulatory disorders or respiratory diseases.

    摘要翻译： 本发明涉及具有下列化学式的肉桂酰胺衍生物：R1表示羟基，C1-6-烷氧基，芳基烷氧基或取代或未取代的氨基; R2和R3相同或不同，各自表示氢原子， 卤素原子或C 1-4 - 烷基; R 4表示氢原子或C 1-6 - 烷基; R 5表示氢原子，C 1-6 - 烷基或芳基; R 6表示氢原子， C 1-6 - 烷基，氰基或C 1-6 - 烷氧基 - 羰基; W表示氧原子，硫原子，亚氨基，亚甲基，羟基亚甲基或羰基; X和 Y相同或不同，各自表示氧原子或硫原子; m表示0〜2的整数，n表示1〜3的整数， 并且当m为0时，基团-C（R 2）（R 3）-W-可以表示亚乙烯基;或其药学上可接受的盐; 以及含有上述化合物，特别是免疫调节剂，肾病综合征，循环障碍或呼吸系统疾病的预防或治疗剂的药物组合物。

    Compositions and methods for treating nephritis and inhibiting TGF -&bgr; related conditions using pyridylacrylamide derivatives
    2.
    发明授权
    Compositions and methods for treating nephritis and inhibiting TGF -&bgr; related conditions using pyridylacrylamide derivatives 失效
    使用吡啶基丙烯酰胺衍生物治疗肾炎和抑制TGF-β相关病症的组合物和方法

    公开(公告)号：US06313153B1

    公开(公告)日：2001-11-06

    申请号：US09463511

    申请日：2000-01-21

    申请人： Yoshihiro Hasegawa ,  Shouichirou Shindou ,  Tomohisa Hattori ,  Yousuke Yamazaki ,  Tatsuhiro Obata ,  Fumiko Horiuchi ,  Hiroyuki Hayakawa ,  Hiroaki Kumazawa

    发明人： Yoshihiro Hasegawa ,  Shouichirou Shindou ,  Tomohisa Hattori ,  Yousuke Yamazaki ,  Tatsuhiro Obata ,  Fumiko Horiuchi ,  Hiroyuki Hayakawa ,  Hiroaki Kumazawa

    IPC分类号： C07D21342

    CPC分类号： C07D213/56

    摘要： The present invention relates to an agent for treating nephritis and a TGF-&bgr; inhibiting agent comprising as an effective ingredient a pyridylacrylamide derivative represented by the following formula (I): wherein Ar1 is a substituted or unsubstituted pyridyl group, Ar2 is a substituted or unsubstituted phenyl group, R1 is a hydrogen atom, an alkyl group or an aryl group, R2 is a hydrogen atom, an alkyl group, a cyano group or an alkoxycarbonyl group, R3 is a hydrogen atom or an optionally substituted alkyl group, X is an oxygen or sulfur atom, A and B are same or different and each represent a hydrogen atom, a hydroxyl group, an alkoxy group or an alkylthio group, or A and B together form an oxo or thioxo group, or a group represented by the formula: ═N—Y in which Y is a dialkylamino, hydroxyl, aralkyloxy or alkoxy group, or a group represented by the formula: —Z1—M—Z2— which Z1 and Z2 are same or different and each represent an oxygen or sulfur atom or an imino group optionally substituted by an alkyl group, and M is an alkylene group or a 1,2-phenylene group, or A is a hydroxyl group and B is a 1-alkylimidazol-2-yl group, and n is an integer of 1 to 3, or a pharmaceutically acceptable salt thereof; as well as the pyridylacrylamide derivatives.

    摘要翻译： 本发明涉及治疗肾炎的药剂和TGF-β抑制剂，其包含作为有效成分的下式（I）表示的吡啶基丙烯酰胺衍生物：其中Ar1为取代或未取代的吡啶基，Ar2为取代或未取代的 苯基，R 1为氢原子，烷基或芳基，R 2为氢原子，烷基，氰基或烷氧基羰基，R 3为氢原子或任选取代的烷基，X为 氧或硫原子，A和B相同或不同，各自表示氢原子，羟基，烷氧基或烷硫基，或A和B一起形成氧代或硫代基，或由式 ：= NY，其中Y是二烷基氨基，羟基，芳烷氧基或烷氧基，或由式-Z1-M-Z2-表示的基团，其中Z1和Z2相同或不同，各自表示氧或硫原子或 亚胺基可选择地 由烷基取代，M为亚烷基或1,2-亚苯基，或A为羟基，B为1-烷基咪唑-2-基，n为1〜3的整数， 或其药学上可接受的盐; 以及吡啶基丙烯酰胺衍生物。

    Antenna device
    3.
    发明授权
    Antenna device 有权
    天线设备

    公开(公告)号：US07365685B2

    公开(公告)日：2008-04-29

    申请号：US11256050

    申请日：2005-10-24

    申请人： Shoichi Takeuchi ,  Hiroyuki Hayakawa ,  Koichi Osada ,  Ryuta Sonoda

    发明人： Shoichi Takeuchi ,  Hiroyuki Hayakawa ,  Koichi Osada ,  Ryuta Sonoda

    IPC分类号： H01Q1/38

    CPC分类号： H01Q9/0457 ,  H01Q1/1271

    摘要： A antenna device, which includes a first dielectric substrate having a patch conductor disposed thereon; a second dielectric substrate having a grounding conductor disposed on a confronting substrate surface confronting the patch conductor; and a conductor for electromagnetic coupling, extending from the confronting substrate surface of the second dielectric substrate toward the first dielectric substrate, is provided. The antenna device is small and is capable of being mounted to a windowpane for a vehicle since the conductor for electromagnetic coupling is not connected to the grounding conductor with respect to a direct current and since the conductor for electromagnetic coupling and the patch conductor are electromagnetically coupled each other.

    摘要翻译： 一种天线装置，其包括：第一电介质基板，其具有布置在其上的贴片导体; 第二电介质基板，具有布置在与所述贴片导体相对的相对基板表面上的接地导体; 以及从第二电介质基板的面对基板表面向第一电介质基板延伸的用于电磁耦合的导体。 天线装置很小，并且能够安装到用于车辆的窗玻璃，因为用于电磁耦合的导体相对于直流电流没有连接到接地导体，并且由于用于电磁耦合的导体和贴片导体被电磁耦合 彼此。

    Method and apparatus for separating thigh meat and oyster meat
    7.
    发明申请
    Method and apparatus for separating thigh meat and oyster meat 失效
    分离大腿肉和牡蛎肉的方法和设备

    公开(公告)号：US20060194532A1

    公开(公告)日：2006-08-31

    申请号：US11312829

    申请日：2005-12-20

    申请人： Hiroyuki Hayakawa ,  Katsuhiro Hayakawa ,  Koji Kido

    发明人： Hiroyuki Hayakawa ,  Katsuhiro Hayakawa ,  Koji Kido

    IPC分类号： A22C17/04

    CPC分类号： A22C21/0023 ,  A22C21/0076

    摘要： A method and apparatus are provided for separating thigh meat and oyster meat from the thighbone automatically without detecting the boundary of the white cap at an end of the thigh bone and the meat including thigh meat and oyster meat and inserting a cutter into the detected boundary part in the final operation of deboning a thigh-with-bone of an edible beast and bird. The apparatus of the invention for separating thigh meat and oyster meat is composed of a clamper 15, a Y-shaped guide-with-a-groove 20, and a Y-shaped guide-with-a-cutter 16 downstream of the guide 20 provided on the transfer line of the clamper, both guides being provided such that the open end side of Y-shape of each guide is directed toward upstream of transfer of the clamper.

    摘要翻译： 提供了一种方法和装置，用于自动分离大腿肉和牡蛎肉，而不检测大腿末端的白帽和包括大腿肉和牡蛎肉在内的白盖的边界，并将切割器插入检测到的边界部分 在可食用的野兽和鸟的大腿骨的最终操作中。 用于分离大腿肉和牡蛎肉的本发明的装置由引导件20下游的夹持器15，Y形导向槽20和Y形导向件16构成。 设置在夹持器的传送线上，两个引导件设置成使得每个引导件的Y形的开口端侧指向夹持器的传送的上游。