发明授权
US06416735B1 Ligands for &agr;-7 nicotinic acetylcholine receptors based on methyllcaconitine
失效
用于基于甲基赖氨酸的α-7烟碱乙酰胆碱受体的配体
- 专利标题： Ligands for &agr;-7 nicotinic acetylcholine receptors based on methyllcaconitine
- 专利标题（中）： 用于基于甲基赖氨酸的α-7烟碱乙酰胆碱受体的配体
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申请号： US09435614申请日： 1999-11-08
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公开(公告)号： US06416735B1公开(公告)日： 2002-07-09
- 发明人: Frank Ivy Carroll , Hernán A. Navarro , Philip Abraham , Desong Zhong
- 申请人： Frank Ivy Carroll , Hernán A. Navarro , Philip Abraham , Desong Zhong
- 主分类号： A61K5100
- IPC分类号： A61K5100
摘要：
Ligands for nAChRs are provided based on various derivatives of methyllycaconitine (MLA) such as radiolabeled MLA, and MLA containing a fluorimetric marker group and their use in imaging for detection of Alzheimer's and other CNS diseases, and combinatorial assays for detection of compounds having affinity for nAChRs, as well as injectable compositions containing the same and kits for performing the imaging studies.
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