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    Ligands for &agr;-7 nicotinic acetylcholine receptors based on methyllcaconitine
    1.
    发明授权
    Ligands for &agr;-7 nicotinic acetylcholine receptors based on methyllcaconitine 失效
    用于基于甲基赖氨酸的α-7烟碱乙酰胆碱受体的配体

    公开(公告)号：US06416735B1

    公开(公告)日：2002-07-09

    申请号：US09435614

    申请日：1999-11-08

    申请人： Frank Ivy Carroll ,  Hernán A. Navarro ,  Philip Abraham ,  Desong Zhong

    发明人： Frank Ivy Carroll ,  Hernán A. Navarro ,  Philip Abraham ,  Desong Zhong

    IPC分类号： A61K5100

    CPC分类号： C07D221/24 ,  A61K51/0455

    摘要： Ligands for nAChRs are provided based on various derivatives of methyllycaconitine (MLA) such as radiolabeled MLA, and MLA containing a fluorimetric marker group and their use in imaging for detection of Alzheimer's and other CNS diseases, and combinatorial assays for detection of compounds having affinity for nAChRs, as well as injectable compositions containing the same and kits for performing the imaging studies.

    摘要翻译： 用于nAChRs的配体是基于甲基绞肉碱（MLA）的各种衍生物（例如放射性标记的MLA）和含有荧光标记物组的MLA及其在成像中用于检测阿尔茨海默氏症和其他CNS疾病的组合提供的，以及用于检测具有亲和力的化合物的组合测定 nAChRs，以及含有其的可注射组合物和用于进行成像研究的试剂盒。

    Monoclonal antibody antagonists for treating medical problems associated with d-amphetamine-like drugs
    6.
    发明授权
    Monoclonal antibody antagonists for treating medical problems associated with d-amphetamine-like drugs 有权
    用于治疗与苯丙胺类药物相关的医疗问题的单克隆抗体拮抗剂

    公开(公告)号：US07202348B2

    公开(公告)日：2007-04-10

    申请号：US10255462

    申请日：2002-09-26

    申请人： Samuel M. Owens ,  Frank Ivy Carroll ,  Philip Abraham

    发明人： Samuel M. Owens ,  Frank Ivy Carroll ,  Philip Abraham

    IPC分类号： C07K16/44

    CPC分类号： A61K31/13 ,  A61K2039/505 ,  C07B2200/07 ,  C07C217/60 ,  C07C233/18 ,  C07K16/44 ,  C07K2317/55

    摘要： The present invention provides synthetic immunochemical haptens for the generation of antibodies that are designed to recognize the common molecular features of d-methamphetamine-like abused stimulants with insignificant cross-reactivity to endogenous substrates (e.g. dopamine) or over-the-counter medications (e.g. 1-methamphetamine, pseudoephedrine, phenylpropanolamine and ephedrine). These monoclonal antibodies and their antigen binding fragments are useful in treatment plans for recovering addicts, in emergency room settings for rapidly reversing a drug overdose, in protection of fetuses from drug-abusing pregnant mothers or in a psychiatric setting to reduce the exacerbation of psychotic disorders caused by stimulant drugs.

    摘要翻译： 本发明提供用于产生抗体的合成免疫化学半抗原，其被设计用于识别对内源底物（例如多巴胺）或非处方药物（例如，多巴胺）具有不显着交叉反应性的d-甲基苯丙胺样滥用兴奋剂的共同分子特征。 1-甲基苯丙胺，伪麻黄碱，苯丙醇胺和麻黄碱）。 这些单克隆抗体及其抗原结合片段可用于恢复吸毒者的急救室设置，用于快速逆转药物过量的治疗计划，保护胎儿免受吸毒怀孕母亲或精神病治疗，以减少精神病的恶化 由兴奋剂引起的。

    Monoclonal antibody antagonists for treating medical problems associated with d-amphetamine-like drugs
    7.
    发明授权
    Monoclonal antibody antagonists for treating medical problems associated with d-amphetamine-like drugs 有权
    用于治疗与苯丙胺类药物相关的医疗问题的单克隆抗体拮抗剂

    公开(公告)号：US06669937B2

    公开(公告)日：2003-12-30

    申请号：US09839549

    申请日：2001-04-20

    申请人： Samuel M. Owens ,  Frank Ivy Carroll ,  Philip Abraham

    发明人： Samuel M. Owens ,  Frank Ivy Carroll ,  Philip Abraham

    IPC分类号： A61K39395

    CPC分类号： C07K16/44 ,  A61K2039/505 ,  C07B2200/07 ,  C07C217/60 ,  C07C233/18 ,  C07K2317/55

    摘要： The invention includes synthetic immunochemical haptens for the generation of antibodies, the antibodies, and the medical treatment applications for using the antibodies. The antibodies are designed to recognize the common molecular features of d-methamphetamine-like abused stimulants, and will have insignificant cross-reactivity with endogenous substrates (e.g. dopamine) or over-the-counter medications (e.g. 1-methamphetamine, pseudoephedrine, phenylpropanolamine and ephedrine). These monoclonal antibodies and their antigen binding fragments are useful in treatment plans for recovering addicts, in emergency room settings for rapidly reversing a drug overdose, in protection of fetuses or fetus from drug-abusing pregnant mothers or in a psychiatric setting to reduce the exacerbation of psychotic disorders caused by stimulant drugs.

    摘要翻译： 本发明包括用于产生抗体的合成免疫化学半抗原，抗体和用于使用抗体的医疗治疗应用。 这些抗体被设计成识别出甲基苯丙胺类滥用兴奋剂的常见分子特征，并且将与内源底物（如多巴胺）或非处方药（例如1-甲基苯丙胺，伪麻黄碱，苯丙醇胺和 麻黄碱）。 这些单克隆抗体及其抗原结合片段可用于恢复吸毒成瘾者的急救室设置，以迅速逆转药物过量，保护胎儿或胎儿免受滥用怀孕母亲或精神病治疗的治疗计划，以减少恶化 兴奋剂引起的精神病。