发明授权
- 专利标题: Antibacterial agents
- 专利标题(中): 抗菌剂
-
申请号: US09355489申请日: 2000-01-07
-
公开(公告)号: US06423690B1公开(公告)日: 2002-07-23
- 发明人: Michael George Hunter , Raymond Paul Beckett , John Martin Clements , Mark Whittaker , Stephen John Davies , Lisa Marie Pratt , Zoe Marie Spavold , Steven Launchbury
- 申请人: Michael George Hunter , Raymond Paul Beckett , John Martin Clements , Mark Whittaker , Stephen John Davies , Lisa Marie Pratt , Zoe Marie Spavold , Steven Launchbury
- 优先权: GB9802549 19980207; GB9806300 19980324; GB9810463 19980516; GB9828318 19981222
- 主分类号: A61K3116
- IPC分类号: A61K3116
摘要:
A method for the treatment of bacterial infections in humans and non-human mammals, which comprises administering to a subject suffering such infection an antibacterially effective dose of a compound of formula (I) or a pharmaceutically or veterinarily acceptable salt thereof: wherein: R1 represents hydrogen, or C1-C6 alkyl or C1-C6 alkyl substituted by one or more halogen atoms; R2 represents a group R10—(X)n—(ALK)m— wherein R10 represents hydrogen, or a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, aryl, or heterocyclyl group, any of which may be unsubstituted or substituted by (C1-C6)alkyl, (C1-C6)alkoxy, hydroxy, mercapto, (C1-C6)alkylthio, amino, halo (including fluoro, chloro, bromo and iodo), trifluoromethyl, cyano, nitro, —COOH, —CONH2, —COORA, —NHCORA, —CONHRA, NHRA, —NRARB, or —CONRARB wherein RA and RB are independently a (C1-C6)alkyl group, and ALK represents a straight or branched divalent C1-C6 alkylene, C2-C6 alkenylene, or C2-C6 alkynylene radical, and may be interrupted by one or more non-adjacent —NH—, —O— or —S—linkages, X represents —NH—, —O— or —S—, and m and n are independently 0 or 1; and A represents a group as defined in the specification.
信息查询