发明授权
- 专利标题： Process for producing isocoumarines and intermediates for the same
- 专利标题（中）： 生产异香豆素及其中间体的方法
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申请号： US09610362申请日： 2000-07-05
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公开(公告)号： US06426420B1公开(公告)日： 2002-07-30
- 发明人: Toshio Tsuchida , Hazuki Nagai , Takashi Nakashima , Masashi Yoshida , Kaname Konuki , Asako Kuroda , Kunio Isshiki , Tomio Takeuchi
- 申请人： Toshio Tsuchida , Hazuki Nagai , Takashi Nakashima , Masashi Yoshida , Kaname Konuki , Asako Kuroda , Kunio Isshiki , Tomio Takeuchi
- 优先权： JP11-207863 19990722; JP11-212239 19990727; JP11-334471 19991125; JP11-336555 19991126
- 主分类号： C07D31176
- IPC分类号： C07D31176
摘要：
Provided is a process for producing an isocoumarin-3-yl-acetic acid derivative, characterized by reacting a homophthalic acid derivative represented by a formula: (wherein Rc, R2 and R are mainly protecting groups) with a malonic acid derivating represented by a formula: (wherein R is an organic group including a lower alkyl group; R3 is a protecting group for a carboxyl group; and X is a halogen atom or a —OM group (wherein M is alkaline metal or alkaline earth metal)). According to the above process, various isocoumarin-3-yl-acetic acid derivatives can efficiently be provided.
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