发明授权
- 专利标题： Compositions and methods for inducing gene expression
- 专利标题（中）： 诱导基因表达的组合物和方法
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申请号： US09579897申请日： 2000-05-26
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公开(公告)号： US06432927B1公开(公告)日： 2002-08-13
- 发明人: Richard J. Gregory , Karen Vincent
- 申请人： Richard J. Gregory , Karen Vincent
- 主分类号： A61K3170
- IPC分类号： A61K3170
摘要：
The present invention provides recombinant nucleic acid molecules encoding a chimeric transactivator protein including a DNA binding domain of a DNA binding protein and a protein domain capable of transcriptional activation. The present invention also provides recombinant viral and non-viral vectors that are able to infect and/or transfect and sustain expression of a biologically active chimeric transactivator proteins in mammalian cells. Also provided are host cell lines and non-human transgenic animals capable of expressing biologically active chimeric transactivator proteins. In another aspect, compositions and methods for treating or preventing ischemic damage associated with hypoxia-related disorders are provided.