发明授权
US06436967B1 Process for preparing prodrugs of benzenesulfonamide-containing cox-2 inhibitors
有权
制备含苯磺酰胺的cox-2抑制剂的前药的方法
- 专利标题： Process for preparing prodrugs of benzenesulfonamide-containing cox-2 inhibitors
- 专利标题（中）： 制备含苯磺酰胺的cox-2抑制剂的前药的方法
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申请号： US09661859申请日： 2000-09-14
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公开(公告)号： US06436967B1公开(公告)日： 2002-08-20
- 发明人: John J Talley , James W Malecha , Stephen Bertenshaw , Matthew J Graneto , Jeffery Carter , Jinglin Li , Srinivasan Nagarajan , David L Brown , Donald J Rogier, Jr. , Thomas D Penning , Ish K Khanna , Xiangdong Xu , Richard M Weier
- 申请人： John J Talley , James W Malecha , Stephen Bertenshaw , Matthew J Graneto , Jeffery Carter , Jinglin Li , Srinivasan Nagarajan , David L Brown , Donald J Rogier, Jr. , Thomas D Penning , Ish K Khanna , Xiangdong Xu , Richard M Weier
- 主分类号： A61K3144
- IPC分类号： A61K3144
摘要：
This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to prodrugs of compounds which selectively inhibit cyclooxygenase-2. The use of non-steroidal antiinflammatory drugs (NSAIDs) in treating pain and the swelling associated with inflammation also produce severe side effects, including life threatening ulcers. The recent discovery of an inducible enzyme associated with inflammation (“prostaglandin G/H synthase II” or “cyclooxygenase-2 (COX-2)”) provides a viable target of inhibition which more effectively reduces inflammation and produces fewer and less drastic side effects.
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