发明授权
- 专利标题: Inhibitor of cellular proliferation
- 专利标题(中): 抑制细胞增殖
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申请号: US09446880申请日: 2000-03-15
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公开(公告)号: US06448040B1公开(公告)日: 2002-09-10
- 发明人: Craig Young , Friedrich Lottspeich , Adam Otasek
- 申请人: Craig Young , Friedrich Lottspeich , Adam Otasek
- 优先权: EP97110669 19970620
- 主分类号: C12N1500
- IPC分类号: C12N1500
摘要:
The present invention relates to nucleic acid molecules encoding hypusines mutants having the biological activity of an inhibitor of cellular proliferation. The present invention further relates to vectors comprising said nucleic acid molecules, to hosts transformed with said vectors, to methods of producing the polypeptide encoded by the nucleic acid molecule of the invention as well as to the polypeptide itself. In addition, the present invention relates to pharmaceutical and diagnostic compositions comprising one or more of the aforementioned compounds, the methods for synchronizing cell growth and to the use of the vector of the invention in gene therapy.