发明授权
US06462055B2 Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group
失效
含α-甲基苄基的含有苯二胺基团的疱疹病毒的硫脲抑制剂
- 专利标题: Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group
- 专利标题(中): 含α-甲基苄基的含有苯二胺基团的疱疹病毒的硫脲抑制剂
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申请号: US09845428申请日: 2001-04-30
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公开(公告)号: US06462055B2公开(公告)日: 2002-10-08
- 发明人: Jonathan Bloom , Kevin Curran , Martin DiGrandi , Russell Dushin , Stanley Lang , Emily Norton , Adma Ross , Bryan O'Hara
- 申请人: Jonathan Bloom , Kevin Curran , Martin DiGrandi , Russell Dushin , Stanley Lang , Emily Norton , Adma Ross , Bryan O'Hara
- 主分类号: A61K3147
- IPC分类号: A61K3147
摘要:
Compounds having the formula: wherein R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, —CN, —NO2, —CO2R6, —COR6, —OR6, —SR6, —SOR6, —SO2R6, —CONR7R8, —NR6N(R7R8), —N(R7R8) or W-Y-(CH2)n-Z provided that at least one of R1-R5 is not hydrogen; or R1 and R2 or R3 and R4, taken together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R7 and R8, taken together may form a 3 to 7 membered heterocycloalkyl; W is O, NR6, or is absent; Y is —(CO)— or —(CO2)—, or is absent; Z is alkyl of 1 to 4 carbon atoms, —CN, —CO2R6, COR6, —CONR7R8, —OCOR6, —NR6COR7, —OCONR6, —OR6, —SR6, —SOR6, —SO2R6, SR6N(R7R8), —N(R7R8) or phenyl; G is aryl or fused bicyclic heteroaryl; X is a bond, —NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6; useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.
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