发明授权
US06464978B1 Vaccination and methods against multiple sclerosis resulting from pathogenic responses by specific T cell populations
失效
疫苗接种和针对特定T细胞群体致病反应引起的多发性硬化症的方法
- 专利标题： Vaccination and methods against multiple sclerosis resulting from pathogenic responses by specific T cell populations
- 专利标题（中）： 疫苗接种和针对特定T细胞群体致病反应引起的多发性硬化症的方法
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申请号： US08055006申请日： 1993-04-29
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公开(公告)号： US06464978B1公开(公告)日： 2002-10-15
- 发明人: Steven W. Brostoff , Darcy B. Wilson , Lawrence R. Smith , Daniel P. Gold , Dennis J. Carlo
- 申请人： Steven W. Brostoff , Darcy B. Wilson , Lawrence R. Smith , Daniel P. Gold , Dennis J. Carlo
- 主分类号： A61K39395
- IPC分类号： A61K39395
摘要：
The present invention provides vaccines and a means of vaccinating a mammal so as to prevent or control specific T cell mediated pathologies or to treat the unregulated replication of T cells. The vaccine is composed of a T cell receptor (TCR) or a fragment thereof corresponding to a TCR present on the surface of T cells mediating the pathology. The vaccine fragment can be a peptide corresponding to sequences of TCRs characteristic of the T cells mediating said pathology. The vaccine is administered to the mammal in a manner that induces an immunologically effective response so as to affect the course of the disease. The invention additionally provides specific &bgr;-chain variable regions of the T cell receptor, designated V&bgr;6.2/3, V&bgr;6.5, V&bgr;2, V&bgr;5.1, V&bgr;13 and V&bgr;7, which are central to the pathogenesis of multiple sclerosis (MS).
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