-
1.发明授权Vaccination and methods against multiple sclerosis resulting from pathogenic responses by specific T cell populations 失效疫苗接种和针对特定T细胞群体致病反应引起的多发性硬化症的方法公开(公告)号：US06464978B1
公开(公告)日：2002-10-15
申请号：US08055006
申请日：1993-04-29
IPC分类号： A61K39395
CPC分类号： G01N33/564 , A61K39/00 , A61K2039/53 , C07K14/7051 , G01N33/56972 , G01N2800/102 , G01N2800/285
摘要： The present invention provides vaccines and a means of vaccinating a mammal so as to prevent or control specific T cell mediated pathologies or to treat the unregulated replication of T cells. The vaccine is composed of a T cell receptor (TCR) or a fragment thereof corresponding to a TCR present on the surface of T cells mediating the pathology. The vaccine fragment can be a peptide corresponding to sequences of TCRs characteristic of the T cells mediating said pathology. The vaccine is administered to the mammal in a manner that induces an immunologically effective response so as to affect the course of the disease. The invention additionally provides specific &bgr;-chain variable regions of the T cell receptor, designated V&bgr;6.2/3, V&bgr;6.5, V&bgr;2, V&bgr;5.1, V&bgr;13 and V&bgr;7, which are central to the pathogenesis of multiple sclerosis (MS).
摘要翻译： 本发明提供疫苗和疫苗接种哺乳动物的手段，以便预防或控制特定的T细胞介导的病理学或治疗T细胞的未调节复制。 疫苗由T细胞受体（TCR）或其对应于存在于介导病理学的T细胞表面上的TCR的片段组成。 疫苗片段可以是对应于介导所述病理学的T细胞特征的TCR序列的肽。 以诱导免疫有效应答以影响疾病进程的方式向哺乳动物施用疫苗。 本发明另外提供T细胞受体的特异性β链可变区，称为Vbet6.2 / 3，Vbeta6.5，Vbeta2，Vbeta5.1，Vbeta13和Vbeta7，它们是多发性硬化（MS）发病机制的核心。
-
公开(公告)号：US5020940A
公开(公告)日：1991-06-04
申请号：US466554
申请日：1990-01-17
申请人： Lawrence R. Smith
发明人： Lawrence R. Smith
CPC分类号： E02B15/08 , E02B15/0814 , E02B15/0864 , E02B15/0878 , E02B15/0885 , Y10S210/923
摘要： An elongated water ballasted oil spill containment boom made of flexible, compact, and easily storable material and having an inner and an outer chambers. When inflated with water the inner chamber assumes a substantially circular cross section and is cylindrical in shape. The selection of the ratio of the size of the outer and inner chambers controls the degree to which the boom floats above the water level and is submerged below the water level. The portions of the boom above and below the water level prevent, respectively, splashover of oil and the escape of oil under the boom. The boom is statically stable in that a strong righting moment tends to automatically properly reorient the boom in the event of undesirable wave, current or wind forces.
摘要翻译： 一种由柔性，紧凑且容易储存的材料制成的细长水压油溢油容器，具有内室和外室。 当用水充气时，内室呈现大致圆形的横截面并且呈圆柱形。 外部和内部空间的大小的比例的选择控制吊杆在水位之上漂浮的程度并且被淹没在水位以下。 水位高低于水位的部分分别防止油的飞溅和起重臂下的油溢出。 吊杆是静态的，因为在不希望有的波浪，电流或风力的情况下，强劲的弯矩倾向于自动正确地重新定向吊臂。
-
公开(公告)号：US5960399A
公开(公告)日：1999-09-28
申请号：US997912
申请日：1997-12-24
CPC分类号： H04L65/602 , G10L15/02 , H04L29/06 , H04M3/4938 , G10L15/30 , H04L29/06027 , H04L67/42 , H04L69/329 , H04M2201/40
摘要： A real-time or streaming speech processing system and method is disclosed with capabilities distributed between and client and a server where the server may be reached via the Internet. The speech processing entails digitizing and converting the utterances to features extracted to help the processing. The features are sent via a communications channel to the server where the recognition occurs. The features extracted allow low bandwidth channels to be used with still maintaining real-time response. The recognizer will determine the most likely text representing the utterances and return the text to the client. The system can be used to identify and/or verify who is speaking.
摘要翻译： 公开了一种实时或流式语音处理系统和方法，其具有分布在客户端之间的能力和可以经由因特网到达服务器的服务器。 语音处理需要将话语数字化并转换为提取的特征以帮助处理。 这些功能通过通信通道发送到发生识别的服务器。 提取的功能允许使用低带宽通道，仍然保持实时响应。 识别器将确定表示话语的最可能的文本，并将文本返回给客户端。 该系统可用于识别和/或验证谁在说话。
-
公开(公告)号：US07092506B1
公开(公告)日：2006-08-15
申请号：US09845486
申请日：2001-04-30
CPC分类号： H04M3/5183 , H04M3/4936
摘要： A system permits a customer service agent to receive and listen to an audio recording from a caller on a voice device (110), and thereby prepare to support the caller before connecting directly with him/her. The incoming call may originate on a public telephone network (120), and be received by a system (100). The system (100) may include one or more of an automatic call distributor/private branch exchange (130), a voice response unit (140), and a computer telephone integration server (160), and possibly a data device (180). The caller may be prompted to provide an audio message concerning the nature of the telephone call. Before being connected to the caller, the service agent may be provided with the audio message from the caller, possibly via the data device (180). After listening to the caller's previously recorded audio message and preparing to assist the caller, the agent and caller may then be directly connected together.
摘要翻译： 系统允许客户服务代理人接收并听取来自语音设备（110）的呼叫者的音频记录，并且因此准备在直接与他/她连接之前支持呼叫者。 来电可以起源于公共电话网络（120），并且由系统（100）接收。 系统（100）可以包括自动呼叫分配器/专用小交换机（130），语音应答单元（140）和计算机电话集成服务器（160）中的一个或多个，以及可能的数据设备（180）。 可以提示呼叫者提供关于电话呼叫的性质的音频消息。 在连接到呼叫者之前，服务代理可能可能通过数据设备（180）从呼叫者提供音频消息。 听完呼叫者以前记录的音频消息并准备协助呼叫者之后，代理和呼叫者可以直接连接在一起。
-
-
-
搜索结果
4 条记录 (耗时 0.025 秒)
