发明授权
US06475487B2 Treatment of a patient by administering an antibody that inhibits cathepsin O
失效
通过施用抑制组织蛋白酶O的抗体来治疗患者
- 专利标题： Treatment of a patient by administering an antibody that inhibits cathepsin O
- 专利标题（中）： 通过施用抑制组织蛋白酶O的抗体来治疗患者
-
申请号： US09953956申请日： 2001-09-18
-
公开(公告)号： US06475487B2公开(公告)日： 2002-11-05
- 发明人: Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H Drake , Maxine Gowan
- 申请人： Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H Drake , Maxine Gowan
- 主分类号： A61K39395
- IPC分类号： A61K39395
摘要：
Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases. A patient is treated by administering an antibody produced against a polypeptide consisting of SEQ ID NO: 2.
公开/授权文献
- US20020072107A1 Human osteoclast derived cathepsin 公开/授权日：2002-06-13
信息查询
