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公开(公告)号：US20080317754A1
公开(公告)日：2008-12-25
申请号：US11756638
申请日：2007-06-01
申请人： Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
发明人： Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
IPC分类号： A61K39/395 , C12N15/11 , C12N15/00 , C12N1/20 , C12P21/04 , G01N33/53 , A61P31/00 , C12N9/50 , C07K16/18 , A61K38/43 , A61K31/7088
CPC分类号： C12N9/6472 , A61K38/00 , C07K16/40
摘要： Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.
摘要翻译： 公开了一种人破骨细胞来源的组织蛋白酶（组织蛋白酶O）多肽和编码这种组织蛋白酶O多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法。 本发明还公开了这种多肽的抗体，拮抗剂和抑制剂，其可用于预防这种多肽的作用，因此可用于治疗性治疗骨疾病如骨质疏松症和癌症如肿瘤转移。
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公开(公告)号：US06387682B1
公开(公告)日：2002-05-14
申请号：US08798096
申请日：1997-02-12
申请人： Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
发明人： Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
IPC分类号： C12N964
CPC分类号： C12N9/6472 , A61K38/00 , C07K16/40
摘要： Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.
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公开(公告)号：US06383793B1
公开(公告)日：2002-05-07
申请号：US08915095
申请日：1997-08-20
申请人： Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
发明人： Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
IPC分类号： C12N964
CPC分类号： C12N9/6472 , A61K38/00 , C07K16/40
摘要： Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.
摘要翻译： 公开了一种人破骨细胞来源的组织蛋白酶（组织蛋白酶O）多肽和编码这种组织蛋白酶O多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法。 本发明还公开了这种多肽的抗体，拮抗剂和抑制剂，其可用于预防这种多肽的作用，因此可用于治疗性治疗骨疾病如骨质疏松症和癌症如肿瘤转移。
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4.发明授权Treatment of a patient by administering an antibody that inhibits cathepsin O 失效通过施用抑制组织蛋白酶O的抗体来治疗患者公开(公告)号：US06475487B2
公开(公告)日：2002-11-05
申请号：US09953956
申请日：2001-09-18
申请人： Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H Drake , Maxine Gowan
发明人： Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H Drake , Maxine Gowan
IPC分类号： A61K39395
CPC分类号： C12N9/6472 , A61K38/00 , C07K16/40
摘要： Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases. A patient is treated by administering an antibody produced against a polypeptide consisting of SEQ ID NO: 2.
摘要翻译： 公开了一种人破骨细胞来源的组织蛋白酶（组织蛋白酶O）多肽和编码这种组织蛋白酶O多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法。 本发明还公开了这种多肽的抗体，拮抗剂和抑制剂，其可用于预防这种多肽的作用，因此可用于治疗性治疗骨疾病如骨质疏松症和癌症如肿瘤转移。 通过施用针对由SEQ ID NO：2组成的多肽产生的抗体来治疗患者。
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公开(公告)号：US07235371B2
公开(公告)日：2007-06-26
申请号：US11185877
申请日：2005-07-21
申请人： Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
发明人： Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
CPC分类号： C12N9/6472 , A61K38/00 , C07K16/40
摘要： Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.
摘要翻译： 公开了一种人破骨细胞来源的组织蛋白酶（组织蛋白酶O）多肽和编码这种组织蛋白酶O多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法。 本发明还公开了这种多肽的抗体，拮抗剂和抑制剂，其可用于预防这种多肽的作用，因此可用于治疗性治疗骨疾病如骨质疏松症和癌症如肿瘤转移。
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公开(公告)号：US06994978B2
公开(公告)日：2006-02-07
申请号：US10726645
申请日：2003-12-04
申请人： Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
发明人： Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
CPC分类号： C12N9/6472 , A61K38/00 , C07K16/40
摘要： Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.
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公开(公告)号：US06423507B1
公开(公告)日：2002-07-23
申请号：US08798095
申请日：1997-02-12
申请人： Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
发明人： Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
IPC分类号： C12Q137
CPC分类号： C12N9/6472 , A61K38/00 , C07K16/40
摘要： Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.
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公开(公告)号：US5501969A
公开(公告)日：1996-03-26
申请号：US208007
申请日：1994-03-08
申请人： Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
发明人： Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
IPC分类号： G01N33/53 , A61K31/70 , A61K38/00 , A61K38/46 , A61K38/48 , A61K39/395 , A61K48/00 , A61P19/08 , A61P19/10 , A61P35/00 , A61P43/00 , C07H21/00 , C07H21/02 , C07H21/04 , C07K14/47 , C07K16/40 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/48 , C12N9/50 , C12N9/64 , C12N15/09 , C12N15/11 , C12N15/57 , C12N15/66 , C12P19/34 , C12P21/00 , C12P21/02 , C12P21/08 , C12Q1/37 , G01N33/535 , C12N15/63
CPC分类号： C12N9/6472 , C07K16/40 , A61K38/00
摘要： Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.
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公开(公告)号：US06680375B2
公开(公告)日：2004-01-20
申请号：US10114464
申请日：2002-04-03
申请人： Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
发明人： Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
IPC分类号： C07K1600
CPC分类号： C12N9/6472 , A61K38/00 , C07K16/40
摘要： Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.
摘要翻译： 公开了一种人破骨细胞来源的组织蛋白酶（组织蛋白酶O）多肽和编码这种组织蛋白酶O多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法。 本发明还公开了这种多肽的抗体，拮抗剂和抑制剂，其可用于预防这种多肽的作用，因此可用于治疗性治疗骨疾病如骨质疏松症和癌症如肿瘤转移。
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公开(公告)号：US06475766B1
公开(公告)日：2002-11-05
申请号：US08553125
申请日：1995-11-07
申请人： Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
发明人： Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
IPC分类号： C12N964
CPC分类号： C12N9/6472 , A61K38/00 , C07K16/40
摘要： Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.
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