Reusable pump drive systems are disclosed that utilize pressurized fluids for creating a force on a flexible or moveable surface of a pump chamber of a pumping cartridge. One such system includes a variable sized orifice valve included as part of a fluid supply system, which valve is able to selectively control a fluid pressure applied to the surface of a pump chamber. Other such systems include a switch valve, which is configured to select a first or second fluid supply source within the system for applying a desired pressure to the surface of a pump chamber.