发明授权
- 专利标题: Phthalazine derivatives and remedies for erectile dysfunction
- 专利标题(中): 酞嗪衍生物和勃起功能障碍的治疗方法
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申请号: US09508197申请日: 2000-03-08
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公开(公告)号: US06498159B1公开(公告)日: 2002-12-24
- 发明人: Nobuhisa Watanabe , Norio Karibe , Kazuki Miyazaki , Fumihiro Ozaki , Atsushi Kamada , Shuhei Miyazawa , Yoshimitsu Naoe , Toshihiko Kaneko , Itaru Tsukada , Tadashi Nagakura , Hiroki Ishihara , Kohtarou Kodama , Hideyuki Adachi
- 申请人: Nobuhisa Watanabe , Norio Karibe , Kazuki Miyazaki , Fumihiro Ozaki , Atsushi Kamada , Shuhei Miyazawa , Yoshimitsu Naoe , Toshihiko Kaneko , Itaru Tsukada , Tadashi Nagakura , Hiroki Ishihara , Kohtarou Kodama , Hideyuki Adachi
- 优先权: JP10-037020 19980219; JP10-319540 19981110
- 主分类号: A61K31502
- IPC分类号: A61K31502
摘要:
The present invention provides a phthalazine compound as a therapeutic agent for erectile dysfunction represented by the following formula, a pharmacologically acceptable salt thereof or a hydrate thereof: wherein R1 and R2 are the same as or different from each other and represent a halogen atom, a C1 to C4 alkyl group which may be substituted with a halogen atom, a C1 to C4 alkoxy group which may be substituted with a halogen atom or a cyano group; X represents a cyano group, a nitro group, a halogen atom, a hydroxyimino group which may be substituted or a heteroaryl group which may be substituted; Y represents a heteroaryl group, an aryl group which may be substituted, an alkynyl group which may substituted, an alkenyl group, an alkyl group, an optionally substituted saturated or unsaturated 4- to 8-membered amine ring, and the cyclic amine compound is a monocyclic compound, bicyclic compound or a spiro compound; l is an integer of 1 to 3; provided that the case where l is 1 or 2, X is a cyano group, a nitro group or a chlorine atom, R1 is a chlorine atom, R2 is a methoxy group and Y is a 5- or 6-membered amine ring substituted with a hydroxyl group is excluded.
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