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公开(公告)号：US08252810B2
公开(公告)日：2012-08-28
申请号：US12368069
申请日：2009-02-09
申请人： Fumihiro Ozaki , Motohiro Soejima , Tasuku Ishida , Yoshihiko Norimine , Nobuyuki Kurusu , Eriko Doi , Toshihiko Kaneko , Daiju Hasegawa , Kiyoaki Kobayashi , Noboru Yamamoto
发明人： Fumihiro Ozaki , Motohiro Soejima , Tasuku Ishida , Yoshihiko Norimine , Nobuyuki Kurusu , Eriko Doi , Toshihiko Kaneko , Daiju Hasegawa , Kiyoaki Kobayashi , Noboru Yamamoto
IPC分类号： A01N43/42 , A61K31/44 , C07D221/02
CPC分类号： C07D451/06 , C07D451/02 , C07D451/04 , C07D519/00
摘要： Compounds represented by formula (I) and pharmaceutically acceptable salts thereof have excellent sodium channel inhibitory action and are useful as therapeutic agents and analgesics for various kinds of neuralgia, neuropathy, epilepsy, insomnia, premature ejaculation and the like. wherein Q represents ethylene, etc., R1, R2 and R3 represent hydrogen, etc., X1 represents C1-6 alkylene, etc., X2 represents C1-6 alkylene, etc., A1 represents a 5- to 6-membered heterocyclic group, etc., and A2 represents C6-14 aryl, etc.
摘要翻译： 由式（I）表示的化合物及其药学上可接受的盐具有优异的钠通道抑制作用，可用作各种神经痛，神经病，癫痫，失眠，早泄等的治疗剂和止痛剂。 其中Q表示亚乙基等，R 1，R 2和R 3表示氢等，X 1表示C 1-6亚烷基等，X 2表示C 1-6亚烷基等，A 1表示5〜6元杂环基 等，A2代表C6-14芳基等。
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公开(公告)号：US20070293496A1
公开(公告)日：2007-12-20
申请号：US11880756
申请日：2007-07-23
申请人： Fumihiro Ozaki , Mutsuko Ono , Koki Kawano , Yoshihiko Norimine , Tatsuhiro Onogi , Takashi Yoshinaga , Kiyoaki Kobayashi , Hiroyuki Suzuki , Hiroe Minami , Kohei Sawada
发明人： Fumihiro Ozaki , Mutsuko Ono , Koki Kawano , Yoshihiko Norimine , Tatsuhiro Onogi , Takashi Yoshinaga , Kiyoaki Kobayashi , Hiroyuki Suzuki , Hiroe Minami , Kohei Sawada
IPC分类号： A61K31/4965 , A61K31/44 , A61K31/50 , A61K31/505 , A61P25/04 , C07D401/00 , A61K31/5377 , A61K31/501 , A61K31/445
CPC分类号： C07D401/06 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/5365 , A61K31/55 , C07D401/14 , C07D403/06 , C07D405/14 , C07D413/14 , C07D417/06
摘要： Compounds represented by the following general formula: [wherein X1, X2, X3 and X4 each independently represent a single bond, C1-6 alkylene, etc.; A2 represents optionally substituted phenyl, etc.; A1 represents an optionally substituted 5- to 7-membered heterocyclic group containing —C(=Q1)- (wherein Q1 represents oxygen, sulfur or ═N—R11 (wherein R11 represents hydrogen or C1-6 alkyl)) and nitrogen, etc.; and Z1 represents piperidin-diyl, etc.], salts thereof and hydrates of the foregoing.
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公开(公告)号：US07304083B2
公开(公告)日：2007-12-04
申请号：US10475118
申请日：2002-04-19
申请人： Shuichi Suzuki , Makoto Kotake , Mitsuaki Miyamoto , Tetsuya Kawahara , Akiharu Kajiwara , Ieharu Hishinuma , Kazuo Okano , Syuhei Miyazawa , Richard Clark , Fumihiro Ozaki , Nobuaki Sato , Masanobu Shinoda , Atsushi Kamada , Itaru Tsukada , Fumiyoshi Matsuura , Yoshimitsu Naoe , Taro Terauchi , Yoshiaki Oohashi , Osamu Ito , Hiroshi Tanaka , Takashi Musha , Motoji Kogushi , Tsutomu Kawata , Toshiyuki Matsuoka , Hiroko Kobayashi , Ken-ichi Chiba , Akifumi Kimura , Naoto Ono
发明人： Shuichi Suzuki , Makoto Kotake , Mitsuaki Miyamoto , Tetsuya Kawahara , Akiharu Kajiwara , Ieharu Hishinuma , Kazuo Okano , Syuhei Miyazawa , Richard Clark , Fumihiro Ozaki , Nobuaki Sato , Masanobu Shinoda , Atsushi Kamada , Itaru Tsukada , Fumiyoshi Matsuura , Yoshimitsu Naoe , Taro Terauchi , Yoshiaki Oohashi , Osamu Ito , Hiroshi Tanaka , Takashi Musha , Motoji Kogushi , Tsutomu Kawata , Toshiyuki Matsuoka , Hiroko Kobayashi , Ken-ichi Chiba , Akifumi Kimura , Naoto Ono
IPC分类号： A61K31/415 , C07D233/00 , C07D233/44 , C07D233/66
CPC分类号： C07D209/44
摘要： A 2-iminoimidazole derivative represented by the formula: {wherein R1, R2 and R3 represent hydrogen, optionally substituted C1-6 alkyl, etc.; R6 represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, etc.; Y1 represents a single bond, —CH2—, etc.; Y2 represents a single bond, —CO—, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R10–R14 represent hydrogen, C1-6 alkyl, hydroxyl, C1-6 alkoxy, etc., and R11 and R12 or R12 and R13 may bond together to form a 5- to 8-membered heterocycle], etc.}or salt thereof.
摘要翻译： 由下式表示的2-亚氨基咪唑衍生物：
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4.发明授权公开(公告)号：US07265108B2
公开(公告)日：2007-09-04
申请号：US11173099
申请日：2005-07-01
申请人： Fumihiro Ozaki , Mutsuko Ono , Koki Kawano , Yoshihiko Norimine , Tatsuhiro Onogi , Takashi Yoshinaga , Kiyoaki Kobayashi , Hiroyuki Suzuki , Hiroe Minami , Kohei Sawada
发明人： Fumihiro Ozaki , Mutsuko Ono , Koki Kawano , Yoshihiko Norimine , Tatsuhiro Onogi , Takashi Yoshinaga , Kiyoaki Kobayashi , Hiroyuki Suzuki , Hiroe Minami , Kohei Sawada
IPC分类号： A62K31/535 , A62K31/4965 , C07D498/00 , C07D413/00 , C07D241/02
CPC分类号： C07D401/06 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/5365 , A61K31/55 , C07D401/14 , C07D403/06 , C07D405/14 , C07D413/14 , C07D417/06
摘要： Compounds represented by the following general formula: [wherein X1, X2, X3 and X4 each independently represent a single bond, C1-6 alkylene, etc.; A2 represents optionally substituted phenyl, etc.; A1 represents an optionally substituted 5- to 7-membered heterocyclic group containing —C(=Q1)- (wherein Q1 represents oxygen, sulfur or ═N—R11 (wherein R11 represents hydrogen or C1-6 alkyl)) and nitrogen, etc.; and Z1 represents piperidin-diyl, etc.], salts thereof and hydrates of the foregoing.
摘要翻译： 由以下通式表示的化合物：其中X 1，X 2，X 3和X 4各自 独立地表示单键，C 1-6亚烷基等; A 2是任选取代的苯基等; A 1是代表任选取代的含有-C（= Q 1） - 的杂环基团（其中Q 1表示氧原子） ，硫或-NR 11（其中R 11表示氢或C 1-6烷基））和氮等; 和Z 1表示哌啶二基等]，其盐和上述的水合物。
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公开(公告)号：US20050004204A1
公开(公告)日：2005-01-06
申请号：US10475188
申请日：2002-04-19
申请人： Shuichi Suzuki , Makoto Kotake , Mitsuaki Miyamoto , Tetsuya Kawahara , Akiharu Kajiwara , Ieharu Hishinuma , Kazuo Okano , Syuhei Miyazawa , Richard Clark , Fumihiro Ozaki , Nobuaki Sato , Masanobu Shinoda , Atsushi Kamada , Itaru Tsukada , Fumiyoshi Matsuura , Yoshimitsu Naoe , Taro Terauchi , Yoshiaki Oohashi , Osamu Ito , Hiroshi Tanaka , Takashi Musha , Motoji Kogushi , Tsutomu Kawata , Toshiyuki Matsuoka , Hiroko Kobayashi , Ken-ichi Chiba , Akifumi Kimura , Naoto Ono
发明人： Shuichi Suzuki , Makoto Kotake , Mitsuaki Miyamoto , Tetsuya Kawahara , Akiharu Kajiwara , Ieharu Hishinuma , Kazuo Okano , Syuhei Miyazawa , Richard Clark , Fumihiro Ozaki , Nobuaki Sato , Masanobu Shinoda , Atsushi Kamada , Itaru Tsukada , Fumiyoshi Matsuura , Yoshimitsu Naoe , Taro Terauchi , Yoshiaki Oohashi , Osamu Ito , Hiroshi Tanaka , Takashi Musha , Motoji Kogushi , Tsutomu Kawata , Toshiyuki Matsuoka , Hiroko Kobayashi , Ken-ichi Chiba , Akifumi Kimura , Naoto Ono
IPC分类号： A61K20060101 , A61K31/403 , A61K31/4035 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/437 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/538 , A61P20060101 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P19/10 , A61P25/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07D20060101 , C07D207/22 , C07D207/24 , C07D207/26 , C07D207/263 , C07D207/267 , C07D207/34 , C07D209/44 , C07D209/52 , C07D209/54 , C07D209/62 , C07D209/96 , C07D213/73 , C07D213/74 , C07D233/46 , C07D233/66 , C07D233/88 , C07D233/90 , C07D235/30 , C07D249/14 , C07D261/14 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D409/04 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/10 , C07D471/04 , C07D487/04 , C07D491/10 , C07D498/04 , C07D521/00 , A61K31/404 , C07D209/30
CPC分类号： C07D209/44
摘要： A 2-iminopyrrolidine derivative represented by the formula: {wherein ring B represents a benzene ring, pyridine ring, etc.; R101-R103 represent hydrogen, halogen, C1-6 alkyl, etc.; R5 represents hydrogen, C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, etc.; R6 represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, etc.; Y1 represents a single bond, —CH2—, etc.; Y2 represents a single bond, —CO—, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R10—R14 represent hydrogen, C1-6 alkyl, hydroxyl, C1-6 alkoxy, etc.; and R11 and R12 or R12 and R13 may bond together to form a 5- to 8-membered heterocyclic ring], etc.}, or a salt thereof.
摘要翻译： 由下式表示的2-亚氨基吡咯烷衍生物：其中环B表示苯环，吡啶环等; R 101 -R 103代表氢，卤素，C 1-6烷基等; R 5表示氢，C 1-6烷基，C 1-6烷氧基-C 1-6烷基等; R 6表示氢，C 1-6烷基，C 1-6烷氧羰基等; Y 1表示单键，-CH 2 - 等; Y 2表示单键，-CO-等; 并且Ar表示氢，由下式表示的基团：其中R 10 -R 14表示氢，C 1-6烷基，羟基，C 1-6烷氧基等; 和R 11和R 12或R 12和R 13可以键合在一起形成5-至8-元杂环]等，或其盐。
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公开(公告)号：US06699870B2
公开(公告)日：2004-03-02
申请号：US10281194
申请日：2002-10-28
申请人： Nobuhisa Watanabe , Norio Karibe , Kazuki Miyazaki , Fumihiro Ozaki , Atsushi Kamada , Shuhei Miyazawa , Yoshimitsu Naoe , Toshihiko Kaneko , Itaru Tsukada , Tadashi Nagakura , Hiroki Ishihara , Kohtarou Kodama , Hideyuki Adachi
发明人： Nobuhisa Watanabe , Norio Karibe , Kazuki Miyazaki , Fumihiro Ozaki , Atsushi Kamada , Shuhei Miyazawa , Yoshimitsu Naoe , Toshihiko Kaneko , Itaru Tsukada , Tadashi Nagakura , Hiroki Ishihara , Kohtarou Kodama , Hideyuki Adachi
IPC分类号： A61K31502
CPC分类号： C07D231/12 , C07D233/56 , C07D237/28 , C07D237/34 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D409/14 , C07D411/14 , C07D417/04 , C07D417/14 , C07D451/06 , C07D471/08 , C07D491/04 , C07D491/08 , C07D491/10
摘要： The present invention provides a phthalazine compound as a therapeutic agent for erectile dysfunction represented by the following formula, a pharmacologically acceptable salt thereof or a hydrate thereof: wherein R1 and R2 are the same as or different from each other and represent a halogen atom, a C1 to C4 alkyl group which may be substituted with a halogen atom, a C1 to C4 alkoxy group which may be substituted with a halogen atom or a cyano group; X represents a cyano group, a nitro group, a halogen atom, a hydroxyimino group which may be substituted or a heteroaryl group which may be substituted; Y represents a heteroaryl group, an aryl group which may be substituted, an alkynyl group which may substituted, an alkenyl group, an alkyl group, an optionally substituted saturated or unsaturated 4- to 8-membered amine ring, and the cyclic amine compound is a monocyclic compound, bicyclic compound or a spiro compound; l is an integer of 1 to 3; provided that the case where l is 1 or 2, X is a cyano group, a nitro group or a chlorine atom, R1 is a chlorine atom, R2 is a methoxy group and Y is a 5- or 6-memberred amine ring substituted with a hydroxyl group is excluded.
摘要翻译： 本发明提供作为下式表示的勃起功能障碍治疗剂的酞嗪化合物，其药理学上可接受的盐或其水合物：其中R 1和R 2彼此相同或不同， 可以被卤素原子取代的C1〜C4烷基，可被卤素原子或氰基取代的C1〜C4烷氧基; X表示氰基，硝基，卤素原子，可被取代的羟基亚氨基或可被取代的杂芳基; Y表示可以被取代的杂芳基，可以被取代的芳基，可以被取代的炔基，烯基，烷基，任选取代的饱和或不饱和的4-至8-元胺环，环胺化合物是 单环化合物，双环化合物或螺环化合物; l为1〜3的整数， 条件是其中l为1或2，X为氰基，硝基或氯原子，R 1为氯原子，R 2为甲氧基，Y为5-或6 被羟基取代的胺基环被排除。
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公开(公告)号：US5849741A
公开(公告)日：1998-12-15
申请号：US619621
申请日：1996-04-09
申请人： Nobuhisa Watanabe , Yasuhiro Kabasawa , Yasutaka Takase , Fumihiro Ozaki , Keiji Ishibashi , Kazuki Miyazaki , Masayuki Matsukura , Shigeru Souda , Kazutoshi Miyake , Hiroki Ishihara , Kohtaro Kodama , Hideyuki Adachi
发明人： Nobuhisa Watanabe , Yasuhiro Kabasawa , Yasutaka Takase , Fumihiro Ozaki , Keiji Ishibashi , Kazuki Miyazaki , Masayuki Matsukura , Shigeru Souda , Kazutoshi Miyake , Hiroki Ishihara , Kohtaro Kodama , Hideyuki Adachi
IPC分类号： C07D237/34 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/04 , C07D521/00 , A01K31/50 , C07D237/30
CPC分类号： C07D231/12 , C07D233/56 , C07D237/34 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/04
摘要： A fused pyridazine compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof which exhibits an inhibitory activity against cyclic GMP phosphodiesterase (hereinafter referred to as "cGMP-PDE"). The compounds are useful as preventive and therapeutic agents for diseases for which a cGMP-PDE inhibiting action is efficacious, for example, ischemic heart diseases such as angina pectoris, myocardial infarct and chronic and acute cardiac failure, pulmonary hypertension, arteriosclerosis and bronchial asthma. ##STR1##
摘要翻译： PCT No.PCT / JP95 / 01575 Sec。 371日期：1996年4月9日 102（e）日期1996年4月9日PCT提交1995年8月8日PCT公布。 出版物WO96 / 05176 日期：1996年2月22日由下述通式（I）表示的稠合哒嗪化合物或其对环状GMP磷酸二酯酶具有抑制活性的药理学上可接受的盐（以下称为“cGMP-PDE”）。 所述化合物可用作对于cGMP-PDE抑制作用有效的疾病的预防和治疗剂，例如心绞痛，心肌梗塞，慢性和急性心力衰竭，肺动脉高压，动脉硬化和支气管哮喘等缺血性心脏病。 （一）
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公开(公告)号：US5716993A
公开(公告)日：1998-02-10
申请号：US507476
申请日：1995-09-14
IPC分类号： A61K31/24 , A61K31/41 , A61K31/415 , A61K31/452 , A61P3/00 , C07C217/58 , C07C229/56 , C07C229/64 , C07C237/30 , C07C237/32 , C07C237/40 , C07C237/42 , C07C237/44 , C07C255/57 , C07C255/58 , C07C255/59 , C07C255/60 , C07C311/39 , C07C311/40 , C07C311/51 , C07D211/46 , C07D211/62 , C07D213/40 , C07D213/64 , C07D213/81 , C07D265/26 , C07D295/15 , C07D295/155 , C07D307/33 , C07D317/48 , C07D317/58 , C07D317/60 , C07D405/06 , C07D405/12 , C07D521/00 , A61K31/165
CPC分类号： C07D213/40 , C07C217/58 , C07C229/56 , C07C229/64 , C07C237/30 , C07C237/32 , C07C237/40 , C07C237/42 , C07C237/44 , C07C255/57 , C07C255/58 , C07C255/59 , C07C255/60 , C07C311/39 , C07C311/40 , C07C311/51 , C07D211/46 , C07D211/62 , C07D213/64 , C07D213/81 , C07D231/12 , C07D233/56 , C07D249/08 , C07D265/26 , C07D295/15 , C07D295/155 , C07D307/33 , C07D317/48 , C07D317/58 , C07D405/06 , C07D405/12 , C07C2101/14 , C07C2101/16
摘要： The present invention provides an anthranilic acid derivative having a cGMP-PDE inhibitory activity. An anthranilic acid derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof: ##STR1## �wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 represent the same or different from each other, a hydrogen atom, a halogen atom, a hydroxy group, an optionally halogenated lower alkyl group, an optionally halogenated lower alkoxy group, a nitro group, a hydroxyalkyl group, a cyano group or the like; R.sup.5 and R.sup.6 represent the same or different from each other, a hydrogen atom, a halogen atom, a hydroxy group, a cyano group, an optionally halogenated lower alkyl group, an optionally halogenated lower alkoxy group or the like; W represents a group of the formula: --N.dbd. or --CH.dbd.; R.sup.7 and R.sup.8 represent the same or different from each other, a hydrogen atom, an optionally halogenated lower alkyl group or the like; A represents a hydrogen atom, an optionally halogenated lower alkyl group or the like; Y represents an oxygen atom or a sulfur atom; and n is an integer of 0 to 6!.
摘要翻译： PCT No.PCT / JP94 / 02262 Sec。 371 1995年9月16日第 102（e）1995年9月16日PCT PCT 1994年12月27日PCT公布。 公开号WO95 / 18097 日期：1995年7月6日本发明提供具有cGMP-PDE抑制活性的邻氨基苯甲酸衍生物。 由通式（I）表示的邻氨基苯甲酸衍生物或其药理学上可接受的盐：其中R 1，R 2，R 3和R 4表示相同或不同的氢原子，卤素原子 ，羟基，任选卤代的低级烷基，任选卤代的低级烷氧基，硝基，羟基烷基，氰基等; R5和R6彼此相同或不同，氢原子，卤素原子，羟基，氰基，任选卤代的低级烷基，任选卤代的低级烷氧基等; W表示下式的基团：-N =或-CH =; R 7和R 8表示相同或不同的氢原子，任选卤代的低级烷基等; A表示氢原子，任选卤代的低级烷基等; Y表示氧原子或硫原子; n为0〜6的整数]。
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公开(公告)号：US5606061A
公开(公告)日：1997-02-25
申请号：US531335
申请日：1995-09-20
申请人： Yasuhiro Kabasawa , Fumihiro Ozaki , Keiji Ishibashi , Takashi Hasegawa , Hitoshi Oinuma , Toshiaki Ogawa , Hideyuki Adachi , Hiroshi Katoh , Kohtarou Kodama , Hideto Ohara , Nobuyuki Mori , Norio Minami
发明人： Yasuhiro Kabasawa , Fumihiro Ozaki , Keiji Ishibashi , Takashi Hasegawa , Hitoshi Oinuma , Toshiaki Ogawa , Hideyuki Adachi , Hiroshi Katoh , Kohtarou Kodama , Hideto Ohara , Nobuyuki Mori , Norio Minami
IPC分类号： C07D231/12 , C07D233/92 , C07D233/95 , C07D471/04
CPC分类号： C07D233/92 , C07D471/04
摘要： The present invention provides a thioformamide derivative represented by the following general formula (I) or a pharmacologically acceptable salt thereof, which is highly safe, easy to use, and useful as an excellent hypotensive or heart disease remedy: ##STR1## wherein Y represents ##STR2## or the like [wherein R.sup.7 represents benzyloxy or the like; R.sup.11 and R.sup.12 each represent hydrogen, hydroxyl, benzoyloxy, benzyloxy, ##STR3## (wherein R.sup.14 and R.sup.15 each represent hydrogen, benzyl or the like) or the like];Z represents --CH.sub.2 -- or the like; A represents imidazolyl or imidazopyridyl which may have one or two substituents, or the like; R.sup.1 and R.sup.2 each represent hydrogen, lower alkyl or the like; and R.sup.3 and R.sup.4 each represent hydrogen, lower alkyl or the like.
摘要翻译： 本发明提供由下列通式（I）表示的硫代甲酰胺衍生物或其药理学上可接受的盐，其是高度安全，易于使用的，并且可用作优异的降血压或心脏病治疗药物：其中 Y表示
等[其中R7表示苄氧基等; R 11和R 12各自表示氢，羟基，苯甲酰氧基，苄氧基，（其中R 14和R 15各自表示氢，苄基等）等。 Z表示-CH 2 - 等; A表示可具有一个或两个取代基的咪唑基或咪唑并吡啶等; R 1和R 2各自表示氢，低级烷基等; R 3和R 4各自表示氢，低级烷基等。 -
公开(公告)号：US5382595A
公开(公告)日：1995-01-17
申请号：US959654
申请日：1992-10-13
申请人： Norio Minami , Fumihiro Ozaki , Keiji Ishibashi , Yasuhiro Kabasawa , Megumi Ikemori , Toshiaki Ogawa , Takanori Kawamura
发明人： Norio Minami , Fumihiro Ozaki , Keiji Ishibashi , Yasuhiro Kabasawa , Megumi Ikemori , Toshiaki Ogawa , Takanori Kawamura
IPC分类号： C07C233/40 , C07C235/34 , C07C235/36 , C07C237/12 , C07C237/20 , C07C255/41 , C07C255/57 , C07C317/44 , C07C323/62 , C07D207/08 , C07D207/32 , C07D207/327 , C07D207/38 , C07D211/22 , C07D211/34 , C07D211/58 , C07D211/86 , C07D213/38 , C07D213/56 , C07D213/64 , C07D213/68 , C07D223/16 , C07D233/66 , C07D235/06 , C07D237/14 , C07D241/18 , C07D263/32 , C07D277/30 , C07D317/58 , C07D317/60 , C07D319/18 , C07D405/06 , C07D471/04 , C07D521/00 , A01N43/02 , C07C233/00
CPC分类号： C07D207/08 , C07C233/40 , C07C235/34 , C07C235/36 , C07C237/12 , C07C237/20 , C07C255/41 , C07C255/57 , C07C317/44 , C07C323/62 , C07D207/327 , C07D207/38 , C07D211/22 , C07D211/34 , C07D211/58 , C07D211/86 , C07D213/38 , C07D213/56 , C07D213/64 , C07D213/68 , C07D223/16 , C07D231/12 , C07D233/56 , C07D235/06 , C07D237/14 , C07D241/18 , C07D249/08 , C07D263/32 , C07D277/30 , C07D317/58 , C07D317/60 , C07D319/18 , C07D405/06 , C07D471/04 , C07C2101/08
摘要： A butenoic or propenoic acid derivative having the following formula in which G is an aryl or a heterocyclic ring, R11 and R12 are hydroben or an alkyl, X is sulfur or oxygen, R2 and R3 are hydrogen, an substituent such as an alkyl and J is pyridyl or phenyl having substituents and a heterocyclic ring may be formed between R2, R3 and J is provided here and is useful in the pharmacological field. ##STR1##
摘要翻译： 具有下式的丁烯酸或丙烯酸衍生物，其中G是芳基或杂环，R11和R12是氢化或烷基，X是硫或氧，R2和R3是氢，取代基如烷基和J 在这里提供吡啶基或具有取代基的苯基和可以在R2，R3和J之间形成杂环，并且在药理学领域是有用的。
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