A tire initiated vehicle control system 110 for vehicles 100 is described. The vehicles 100 have vehicle components including a power train 140, a suspension system 180, a steering mechanism 160, a plurality of wheel brake mechanisms 130, one wheel brake mechanism 130 being at each wheel position 104a, 104b, 104c, and 104d location, a fuel or vehicle speed throttle 144 with or without a cruise control system, the vehicle control system 110 has a tire pressure detection device 120 and a control means 200, which preferably has a computer 208 for receiving data from the tire pressure detection device 120. The control means 200 processes the received tire pressure data and upon a preset pressure or rate of change value in tire pressure the control means 208 directs a change in response rates of one or more of the above listed vehicle components.