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Invention Grant
US06500944B2 Sulfurizing reagent: 3-aryl-1,2,4-dithiazoline-5-ones 失效
硫化试剂：3-芳基-1,2,4-二噻唑啉-5-酮

  • Patent Title: Sulfurizing reagent: 3-aryl-1,2,4-dithiazoline-5-ones
  • Patent Title (中): 硫化试剂：3-芳基-1,2,4-二噻唑啉-5-酮
  • Application No.: US08895136
    Application Date: 1997-07-16
  • Publication No.: US06500944B2
    Publication Date: 2002-12-31
  • Inventor: Saroj K. Roy , Jin-Yan Tang
  • Applicant: Saroj K. Roy , Jin-Yan Tang
  • Main IPC: C07H2100
  • IPC: C07H2100
Sulfurizing reagent: 3-aryl-1,2,4-dithiazoline-5-ones
Abstract:
The invention relates to the chemical synthesis of oligonucleotides and to chemical entities useful in such synthesis. More particularly, the invention relates to sulfurization of the internucleotide linkages of oligonucleotides. The invention provides a process to synthesize new sulfur transfer reagents and a process for their use in sulfurizing oligonucleotides. The sulfur transfer reagents according to the invention are inexpensive to make, stable in storage and in solution, and highly efficient in sulfurization.
Abstract(Chinese):

本发明涉及寡核苷酸的化学合成以及可用于这种合成的化学实体。 更具体地，本发明涉及寡核苷酸的核苷酸间键的硫化。 本发明提供合成新的硫转移试剂的方法及其在硫化寡核苷酸中的用途。 根据本发明的硫转移试剂制备成本低，储存稳定，溶解稳定，硫化效率高。

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