The present invention relates to a device for holding disk-shaped plastic substrates for pick-up and deposit. The device includes a holding device having at least one support unit for the plastic substrates, and a pick-up and/or deposit device on which a plastic substrate is mounted and from which the plastic substrate is picked-up or deposited. The holding device has a recess and the disk-shaped base body has a cylindrical protrusion on its side facing the holding device, which can be plugged into and releasably held mechanically or in a permanent-magnetic way in the recess.