发明授权
- 专利标题： Glucagon antagonists/inverse agonists
- 专利标题（中）： 胰高血糖素拮抗剂/反向激动剂
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申请号： US09572553申请日： 2000-05-16
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公开(公告)号： US06503949B1公开(公告)日： 2003-01-07
- 发明人: Jesper Lau , Peter Madsen , Christian Sams , Carsten Behrens , Josef Vagner , Inge Thøger Christensen , Behrend Frederik Lundt , Ulla Grove Sidelmann , Henning Thøgersen , Anthony L. Ling , Michael Bruno Plewe , Larry Kenneth Truesdale , Shenghua Shi
- 申请人： Jesper Lau , Peter Madsen , Christian Sams , Carsten Behrens , Josef Vagner , Inge Thøger Christensen , Behrend Frederik Lundt , Ulla Grove Sidelmann , Henning Thøgersen , Anthony L. Ling , Michael Bruno Plewe , Larry Kenneth Truesdale , Shenghua Shi
- 优先权： DK199900684 19990517; DK200000478 20000321
- 主分类号： A01N3718
- IPC分类号： A01N3718
摘要：
Disclosed is a novel class of compounds of formula (I) wherein V, A, Y, Z, R1, E, X and D are as defined in the specification. These compounds act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor, the compounds are suitable for treating or preventing glucagon-mediated conditions and diseases such as hyperglycemia, Type 1 diabetes, Type 2 diabetes and obesity.
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