发明授权
US06506876B1 LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use
失效
LTA4水解酶抑制剂药物组合物和使用方法
- 专利标题： LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use
- 专利标题（中）： LTA4水解酶抑制剂药物组合物和使用方法
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申请号： US08321184申请日： 1994-10-11
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公开(公告)号： US06506876B1公开(公告)日： 2003-01-14
- 发明人: Nizal Samuel Chandrakumar , Barbara Baosheng Chen , Michael Clare , Bipinchandra Nanubhai Desai , Stevan Wakefield Djuric , Stephen Hermann Docter , Alan Frank Gasiecki , Richard Arthur Haack , Chi-Dean Liang , Julie Marion Miyashiro , Thomas Dale Penning , Mark Andrew Russell , Stella Siu-tzyy Yu
- 申请人： Nizal Samuel Chandrakumar , Barbara Baosheng Chen , Michael Clare , Bipinchandra Nanubhai Desai , Stevan Wakefield Djuric , Stephen Hermann Docter , Alan Frank Gasiecki , Richard Arthur Haack , Chi-Dean Liang , Julie Marion Miyashiro , Thomas Dale Penning , Mark Andrew Russell , Stella Siu-tzyy Yu
- 主分类号： A01N4340
- IPC分类号： A01N4340
摘要：
The present invention provides compounds of the formula Ar1—Q—Ar2—Y—R—Z and pharmaceutically acceptable salts thereof wherein Ar1 and Ar2 are optionally substituted aryl moieties, Z is an optionally substituted nitrogen-containing moiety which may be an acyclic, cyclic or bicyclic amine or an optionally substituted monocyclic or bicyclic nitrogen-containing heteroaromatic moiety; Q is a linking group capable of linking two aryl groups; R is an alkylene moiety; Y is a linking moiety capable of linking an aryl group to an alkylene moiety and wherein Z is bonded to R through a nitrogen atom. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of inflammatory diseases which are mediated by LTB4 production, such as psoriasis, ulcerative colitis, IBD and asthma.