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公开(公告)号：US07026485B2
公开(公告)日：2006-04-11
申请号：US10793672
申请日：2004-03-05
Applicant: John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Kathryn L. Reed , Ko-Chung Lin , John Nicholas Freskos , Michael Clare , Donald Joseph Rogier, Jr. , Robert M. Heintz , Michael L. Vazquez , Richard A. Mueller
Inventor： John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Kathryn L. Reed , Ko-Chung Lin , John Nicholas Freskos , Michael Clare , Donald Joseph Rogier, Jr. , Robert M. Heintz , Michael L. Vazquez , Richard A. Mueller
IPC: C07D471/00
CPC classification number: C07D401/12 , C07D207/16 , C07D211/60 , C07D217/26
Abstract: N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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公开(公告)号：US06979686B1
公开(公告)日：2005-12-27
申请号：US10021780
申请日：2001-12-07
Applicant: Ashok S. Naraian , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , Richard M. Weier , Xiangdong Xu , Ish K. Khanna , Yi Yu , Win Naing , John Walker , Syaulan Yang
Inventor： Ashok S. Naraian , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , Richard M. Weier , Xiangdong Xu , Ish K. Khanna , Yi Yu , Win Naing , John Walker , Syaulan Yang
IPC: A61K31/496 , A61K31/501 , A61K31/5355 , C07D211/06 , C07D413/04
CPC classification number: C07D401/14 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D473/00 , C07D487/04 , C07D491/10 , C07D495/04
Abstract: A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula (IA), wherein R1, R2, R3 and R4 are as described in the specification.
Abstract translation: 描述了一类吡唑衍生物用于治疗p38激酶介导的病症。 特别感兴趣的化合物由式（IA）定义，其中R 1，R 2，R 3和R 4， SUP>如说明书中所述。
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公开(公告)号：US20050176821A1
公开(公告)日：2005-08-11
申请号：US10657570
申请日：2003-09-08
Applicant: Nizal Chandrakumar , Michael Clare , Wendell Doubleday , Alan Gasiecki , Mark Russell
Inventor： Nizal Chandrakumar , Michael Clare , Wendell Doubleday , Alan Gasiecki , Mark Russell
IPC: A61K31/00 , A61K31/195 , A61K31/415 , A61K31/4164 , A61K31/4168 , A61K31/44 , A61K31/445 , A61P3/00 , A61P3/14 , A61P9/00 , A61P9/10 , A61P35/00 , A61P35/04 , A61P43/00 , C07C311/42 , C07C311/46 , C07C311/47 , C07D211/96 , C07D213/55 , C07D233/50 , C07D295/26 , A61K31/277 , A61K31/18
CPC classification number: C07D295/26 , C07C311/42 , C07C311/46 , C07C311/47 , C07D211/96 , C07D213/55 , C07D233/50
Abstract: The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αvβ3 integrin.
Abstract translation: 本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物和选择性抑制或拮抗α > 3 整联蛋白。
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公开(公告)号：US06900232B2
公开(公告)日：2005-05-31
申请号：US09882186
申请日：2001-06-15
Applicant: Ish Kumar Khanna , Michael Clare , Alan F. Gasiecki , Thomas Rogers , Barbara Chen , Mark Russell , Hwang-Fun Lu
Inventor： Ish Kumar Khanna , Michael Clare , Alan F. Gasiecki , Thomas Rogers , Barbara Chen , Mark Russell , Hwang-Fun Lu
IPC: A61K31/4168 , A61K31/4375 , A61K31/44 , A61K31/4402 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/5383 , A61P3/14 , A61P9/00 , A61P9/10 , A61P19/02 , A61P19/10 , A61P21/00 , A61P27/02 , A61P35/00 , A61P35/04 , C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D498/04 , C07D213/72
CPC classification number: C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: The present invention relates to a class of compounds represented by the Formula I Wherein A1 is a pyridinyl of the formula optionally substituted by one or more Rk selected from the group consisting of hydroxy, alkyl, alkoxy, alkoxyalkyl, thioalkyl, haloalkyl, cyano, amino alkylamino, halogen, acylamino, sulfonamide and —COR; and R is hydroxy, alkoxy, alkyl or amino; and pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αvβ3 and/or αvβ5 integrin.
Abstract translation: 本发明涉及由式I表示的一类化合物，其中A 1是下式的吡啶基，其任选被一个或多个选自下组的R 0选自 羟基，烷基，烷氧基，烷氧基烷基，硫代烷基，卤代烷基，氰基，氨基烷基氨基，卤素，酰氨基，磺酰胺和-COR; 且R为羟基，烷氧基，烷基或氨基; 和其药学上可接受的盐，包含式I化合物的药物组合物，以及选择性抑制或拮抗α3β3和/或α / 5> 5＆lt; 5＆gt;整联蛋白。
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公开(公告)号：US06831199B1
公开(公告)日：2004-12-14
申请号：US09215229
申请日：1998-12-18
Applicant: Peter Gerrard Ruminski , Michael Clare , Paul Waddell Collins , Bipinchandra Nanubhai Desai , Richard John Lindmark , Joseph Gerace Rico , Thomas Edward Rogers , Mark Andrew Russell
Inventor： Peter Gerrard Ruminski , Michael Clare , Paul Waddell Collins , Bipinchandra Nanubhai Desai , Richard John Lindmark , Joseph Gerace Rico , Thomas Edward Rogers , Mark Andrew Russell
IPC: C07C21100
CPC classification number: C07D231/06 , C07C275/42 , C07C279/18 , C07C279/24 , C07C279/28 , C07C311/19 , C07C311/37 , C07C317/50 , C07C323/59 , C07C323/62 , C07C323/63 , C07C335/22 , C07C335/28 , C07D207/14 , C07D211/72 , C07D213/55 , C07D213/61 , C07D215/14 , C07D223/12 , C07D231/12 , C07D231/14 , C07D233/50 , C07D239/14 , C07D239/26 , C07D239/545 , C07D249/14 , C07D295/215 , C07D307/54 , C07D307/79 , C07D307/81 , C07D317/60 , C07D319/18 , C07D333/24 , C07D333/28 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D417/12 , C07H15/203
Abstract: The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, wherein A is pharmaceutical compositions thereof and methods of using such compounds and compositions as &agr;v&bgr;3 antagonists.
Abstract translation: 本发明涉及一类由式I表示的化合物或其药学上可接受的盐，其中A是其药物组合物和使用这些化合物和组合物作为alphavbeta3拮抗剂的方法。
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Patent Agency Ranking
公开(公告)号：US06525059B1
公开(公告)日：2003-02-25
申请号：US09513351
申请日：2000-02-24
Applicant: Ashok Anantanarayan , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , Richard M. Weier , Xiangdong Xu , Ish K. Khanna , Yi Yu
Inventor： Ashok Anantanarayan , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , Richard M. Weier , Xiangdong Xu , Ish K. Khanna , Yi Yu
IPC: A61K31506
CPC classification number: C07D409/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/02 , C07D471/04 , C07D473/00 , C07D487/04
Abstract: A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA wherein R1, R 2, R3 and R4 are as described in the specification.
Abstract translation: 描述了一类吡唑衍生物用于治疗p38激酶介导的病症。 特别感兴趣的化合物由式IA定义，其中R 1，R 2，R 3和R 4如说明书中所述。
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7.发明授权Meta-guanidine, urea, thiourea or azacyclic amino benzoic acid compounds and derivatives thereof 失效元 - 胍，尿素，硫脲或氮杂环丁氨基苯甲酸化合物及其衍生物
公开(公告)号：US6028223A
公开(公告)日：2000-02-22
申请号：US713555
申请日：1996-08-27
Applicant: Peter Gerrard Ruminski , Michael Clare , Paul Waddell Collins , Bipinchandra Nanubhai Desai , Richard John Lindmark , Joseph Gerace Rico , Thomas Edward Rogers , Mark Andrew Russell
Inventor： Peter Gerrard Ruminski , Michael Clare , Paul Waddell Collins , Bipinchandra Nanubhai Desai , Richard John Lindmark , Joseph Gerace Rico , Thomas Edward Rogers , Mark Andrew Russell
IPC: A61K31/00 , A61K31/155 , A61K31/17 , A61K31/195 , A61K31/24 , A61K31/335 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/357 , A61K31/36 , A61K31/38 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4168 , A61K31/4184 , A61K31/4196 , A61K31/44 , A61K31/4406 , A61K31/445 , A61K31/4453 , A61K31/4458 , A61K31/47 , A61K31/505 , A61K31/513 , A61K31/535 , A61K31/5375 , A61K31/54 , A61K31/541 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K38/00 , A61P5/38 , A61P25/06 , A61P35/00 , A61P35/04 , A61P43/00 , C07C275/28 , C07C275/42 , C07C279/18 , C07C279/24 , C07C279/28 , C07C311/19 , C07C311/37 , C07C313/34 , C07C317/50 , C07C323/59 , C07C323/62 , C07C323/63 , C07C335/22 , C07C335/28 , C07D207/14 , C07D207/22 , C07D209/16 , C07D211/72 , C07D213/55 , C07D213/61 , C07D213/74 , C07D215/14 , C07D223/12 , C07D231/06 , C07D231/12 , C07D231/14 , C07D233/50 , C07D233/64 , C07D235/30 , C07D239/14 , C07D239/26 , C07D239/54 , C07D239/545 , C07D249/14 , C07D295/12 , C07D295/14 , C07D295/20 , C07D295/215 , C07D295/22 , C07D307/54 , C07D307/79 , C07D307/81 , C07D317/60 , C07D317/64 , C07D319/18 , C07D319/20 , C07D333/20 , C07D333/24 , C07D333/28 , C07D401/12 , C07D401/14 , C07D405/10 , C07D405/12 , C07D413/12 , C07D417/12 , C07H15/203 , C07K5/062 , C07D211/94 , A61K31/55 , C07C229/00 , C07C335/00
CPC classification number: C07D231/06 , C07C275/42 , C07C279/18 , C07C279/24 , C07C279/28 , C07C311/19 , C07C311/37 , C07C317/50 , C07C323/59 , C07C323/62 , C07C323/63 , C07C335/22 , C07C335/28 , C07D207/14 , C07D211/72 , C07D213/55 , C07D213/61 , C07D215/14 , C07D223/12 , C07D231/12 , C07D231/14 , C07D233/50 , C07D239/14 , C07D239/26 , C07D239/545 , C07D249/14 , C07D295/215 , C07D307/54 , C07D307/79 , C07D307/81 , C07D317/60 , C07D319/18 , C07D333/24 , C07D333/28 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D417/12 , C07H15/203
Abstract: The present invention relates to a class of compounds represented by the Formula I ##STR1## or a pharmaceutically acceptable salt thereof, wherein A is ##STR2## pharmaceutical compositions thereof and methods of using such compounds and compositions as .alpha..sub.v .beta..sub.3 antagonists.
Abstract translation: 本发明涉及一类由式I表示的化合物或其药学上可接受的盐，其中A是其药物组合物，以及使用这些化合物和组合物作为αvβ3拮抗剂的方法。
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公开(公告)号：US5843906A
公开(公告)日：1998-12-01
申请号：US824626
申请日：1997-03-27
Applicant: Nizal Chandrakumar , Michael Clare , Wendell Doubleday , Alan F. Gasiecki , Mark A. Russell
Inventor： Nizal Chandrakumar , Michael Clare , Wendell Doubleday , Alan F. Gasiecki , Mark A. Russell
IPC: A61K31/00 , A61K31/195 , A61K31/415 , A61K31/4164 , A61K31/4168 , A61K31/44 , A61K31/445 , A61P3/00 , A61P3/14 , A61P9/00 , A61P9/10 , A61P35/00 , A61P35/04 , A61P43/00 , C07C311/42 , C07C311/46 , C07C311/47 , C07D211/96 , C07D213/55 , C07D233/50 , C07D295/26 , A61K38/00
CPC classification number: C07D295/26 , C07C311/42 , C07C311/46 , C07C311/47 , C07D211/96 , C07D213/55 , C07D233/50
Abstract: The present invention relates to a class of compounds represented by the Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the .alpha..sub.v .beta..sub.3 integrin.
Abstract translation: 本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物和选择性抑制或拮抗αvβ3整联蛋白的方法。
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公开(公告)号：US5773644A
公开(公告)日：1998-06-30
申请号：US825040
申请日：1997-03-27
Applicant: Barbara B. Chen , Helen Y. Chen , Michael Clare , Shashidhar N. Rao , Mark A. Russell
Inventor： Barbara B. Chen , Helen Y. Chen , Michael Clare , Shashidhar N. Rao , Mark A. Russell
IPC: C07D239/14 , A61K31/00 , A61K31/195 , A61K31/196 , A61K31/215 , A61K31/216 , A61K31/505 , A61P3/00 , A61P3/14 , A61P9/00 , A61P9/10 , A61P35/00 , A61P35/04 , A61P43/00 , C07C279/18 , C07C279/24 , C07D239/42 , C07C241/00 , C07C229/00 , C07D239/00
CPC classification number: C07D239/42 , C07C279/18 , C07C279/24 , C07C2101/02
Abstract: The present invention relates to a class of compounds represented by the Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the .alpha..sub.v .beta..sub.3 integrin.
Abstract translation: 本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物和选择性抑制或拮抗αvβ3整联蛋白的方法。
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公开(公告)号：US5643924A
公开(公告)日：1997-07-01
申请号：US455237
申请日：1995-05-31
Applicant: John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Kathryn L. Reed , Ko-Chung Lin , John Nicholas Freskos , Michael Clare , Donald Joseph Rogier, Jr. , Robert M. Heintz , Michael L. Vazquez , Richard A. Mueller
Inventor： John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Kathryn L. Reed , Ko-Chung Lin , John Nicholas Freskos , Michael Clare , Donald Joseph Rogier, Jr. , Robert M. Heintz , Michael L. Vazquez , Richard A. Mueller
IPC: A61K31/40 , A61K31/4427 , A61K31/445 , A61K31/4468 , A61K31/47 , A61K31/472 , A61K38/55 , A61P31/12 , C07D207/16 , C07D211/60 , C07D217/26 , C07D241/04 , C07D401/12 , C07K5/06 , C07K14/81 , A61K31/44
CPC classification number: C07D401/12 , C07D207/16 , C07D211/60 , C07D217/26
Abstract: N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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