A method of designing a mask-programmable random-access read-only memory device begins with a step of assigning weightings to addresses according to their expected frequency of access. These weighting are used in a second step of determining for each sense amplifier, what is the low-power sense (inverted or uninverted) of the stored bits using that sense amplifier as an output. The third step involves storing the data in the low-power sense. The fourth step involves inverting the outputs for the data that is stored inverted. This can involve using sense inverting sense amplifiers for inverted data and sense preserving amplifiers for uninverted data. The method can result in memories in which some outputs are sense inverting while others are sense preserving. The result is a memory device with reduced power consumption relative to a comparable design not taking advantage of the relationship between data values and power consumption.