发明授权
- 专利标题： Tetralone derivatives
- 专利标题（中）： 四氢萘酮衍生物
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申请号： US10006173申请日： 2001-12-04
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公开(公告)号： US06531472B2公开(公告)日： 2003-03-11
- 发明人: Guy Georges , Adelbert Grossmann , Tim Sattelkau , Wolfgang Schaefer , Ulrich Tibes
- 申请人： Guy Georges , Adelbert Grossmann , Tim Sattelkau , Wolfgang Schaefer , Ulrich Tibes
- 优先权： EP00126820 20001207
- 主分类号： A61K3140
- IPC分类号： A61K3140
摘要：
The present invention provides compounds of formula I and pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, X and Y have the meanings defined in the specification. The compounds have histone deacetylase (HDAC) inhibitory activity which is useful in cancer treatment. Also provided is a process for making a compound of formula I by reacting a compound of formula III with a compound of formula IV wherein A is a displaceable group and PG is a protecting group.
公开/授权文献
- US20020065282A1 Tetralone derivatives 公开/授权日：2002-05-30